Regeneron Pharmaceuticals (REGN) had the highest return between 2011 and 2012 by a large-cap US stock, returning 423.3%.

ASSET	YEARS	% RETURN
Regeneron Pharmaceuticals (REGN)	2011-2012	423.31%
Cheniere Energy (LNG)	2011-2012	234.16%
Domino's Pizza Inc Common Stock (DPZ)	2011-2012	192.28%
Ulta Beauty (ULTA)	2011-2012	191.12%
Builders FirstSource (BLDR)	2011-2012	179%
Expedia (EXPE)	2011-2012	167.15%
Lithia Motors (LAD)	2011-2012	166.24%
Contura Energy (CTRA)	2011-2012	161.16%
PulteGroup (PHM)	2011-2012	138.32%
Tyler Technologies (TYL)	2011-2012	131.33%
Lululemon Athletica (LULU)	2011-2012	119.68%
Visa Inc Class A (V)	2011-2012	118.73%
Seagate Technology (STX)	2011-2012	118.29%
Mastercard (MA)	2011-2012	117.96%
Aspen Technology (AZPN)	2011-2012	116.61%
Biogen (BIIB)	2011-2012	116.27%
LyondellBasell Industries (LYB)	2011-2012	112.44%
Discover Financial Services (DFS)	2011-2012	110.5%
Targa Resources (TRGP)	2011-2012	108.67%
Lennar (LEN)	2011-2012	107.76%
Transdigm (TDG)	2011-2012	106.16%
Monster Beverage (MNST)	2011-2012	100.72%
Gilead Sciences (GILD)	2011-2012	100.46%
Sarepta Therapeutics (SRPT)	2011-2012	100%
Lennar (LEN.B)	2011-2012	98.39%

Large-cap stocks are treated as having a market cap of $10B+.