Moderna (MRNA) had the highest return between 2020 and 2021 by a US stock in the S&P 500 (GSPC), returning 1,197.8%.

ASSET	YEARS	% RETURN
Moderna (MRNA)	2020-2021	1,197.8%
Tesla (TSLA)	2020-2021	1,144.73%
Enphase Energy (ENPH)	2020-2021	593.74%
NVIDIA (NVDA)	2020-2021	393.99%
Carrier Global (CARR)	2020-2021	360.98%
Crowdstrike (CRWD)	2020-2021	309.25%
Generac (GNRC)	2020-2021	247.13%
Builders FirstSource (BLDR)	2020-2021	234.94%
Fortinet (FTNT)	2020-2021	234.01%
Albemarle (ALB)	2020-2021	226.06%
Freeport-McMoran Copper & Gold (FCX)	2020-2021	215.77%
West Pharmaceutical Services (WST)	2020-2021	213.76%
EPAM Systems (EPAM)	2020-2021	212.18%
Advanced Micro Devices (AMD)	2020-2021	207.08%
Old Dominion Freight Line (ODFL)	2020-2021	184.36%
Quanta Services (PWR)	2020-2021	181.01%
Arista Networks (ANET)	2020-2021	179.56%
Monolithic Power Systems (MPWR)	2020-2021	177.85%
ON Semiconductor (ON)	2020-2021	174.42%
Pool (POOL)	2020-2021	170.88%
Cadence Design Systems (CDNS)	2020-2021	165.53%
Synopsys (SNPS)	2020-2021	162.63%
Tractor Supply (TSCO)	2020-2021	160.66%
KKR (KKR)	2020-2021	160.03%
Applied Materials (AMAT)	2020-2021	159.06%