Netflix (NFLX) had the highest return between 2012 and 2017 by a US stock in the S&P 500 (GSPC), returning 1,812%.

ASSET	YEARS	% RETURN
Netflix (NFLX)	2012-2017	1,811.95%
Caesars Entertainment (CZR)	2012-2017	1,663.3%
NVIDIA (NVDA)	2012-2017	1,359.47%
Texas Pacific Land Trust (TPL)	2012-2017	1,046.24%
Constellation Brands Inc Class A (STZ)	2012-2017	1,021.22%
Tesla (TSLA)	2012-2017	975.87%
Builders FirstSource (BLDR)	2012-2017	937.62%
Broadcom (AVGO)	2012-2017	864.36%
Align Technology (ALGN)	2012-2017	816.63%
Monolithic Power Systems (MPWR)	2012-2017	695.66%
Take-Two Interactive Software (TTWO)	2012-2017	693.78%
Huntington Ingalls Industries (HII)	2012-2017	684.97%
Southwest Airlines (LUV)	2012-2017	684.26%
EPAM Systems (EPAM)	2012-2017	681.31%
NXP Semiconductors (NXPI)	2012-2017	642.02%
Delta Air Lines (DAL)	2012-2017	622.53%
MarketAxess (MKTX)	2012-2017	619.36%
Diamondback Energy (FANG)	2012-2017	608.47%
Regeneron Pharmaceuticals (REGN)	2012-2017	565.3%
Amazon (AMZN)	2012-2017	564.89%
Lennox International (LII)	2012-2017	544.85%
Smith AO (AOS)	2012-2017	542.72%
Corpay (CPAY)	2012-2017	542.08%
Incyte (INCY)	2012-2017	529.3%
Domino's Pizza Inc Common Stock (DPZ)	2012-2017	525.71%