Caesars Entertainment (CZR) had the highest return between 2010 and 2017 by a US stock in the S&P 500 (GSPC), returning 2,450%.

ASSET	YEARS	% RETURN
Caesars Entertainment (CZR)	2010-2017	2,450%
Domino’s Pizza (DPZ)	2010-2017	2,436.58%
Netflix (NFLX)	2010-2017	2,320.25%
United Rentals (URI)	2010-2017	1,632.97%
Tesla (TSLA)	2010-2017	1,538.64%
MarketAxess (MKTX)	2010-2017	1,531.28%
Broadcom (AVGO)	2010-2017	1,477.15%
Regeneron Pharmaceuticals (REGN)	2010-2017	1,450.99%
Texas Pacific Land Trust (TPL)	2010-2017	1,434.47%
Constellation Brands Inc Class A (STZ)	2010-2017	1,366.97%
Align Technology (ALGN)	2010-2017	1,130.97%
Ulta Beauty (ULTA)	2010-2017	1,076.09%
Charter Communications (CHTR)	2010-2017	1,057.52%
NVIDIA (NVDA)	2010-2017	1,027.59%
Take-Two Interactive Software (TTWO)	2010-2017	978.39%
Incyte (INCY)	2010-2017	927.22%
Transdigm (TDG)	2010-2017	885.71%
Monster Beverage (MNST)	2010-2017	882.28%
Old Dominion Freight Line (ODFL)	2010-2017	867.93%
Centene (CNC)	2010-2017	842.8%
Smith AO (AOS)	2010-2017	835.62%
NXP Semiconductors (NXPI)	2010-2017	800.7%
Tyler Technologies (TYL)	2010-2017	783.04%
Amazon (AMZN)	2010-2017	758.33%
Ross Stores (ROST)	2010-2017	714.47%