XTI Aerospace (XTIA) had the highest return in the 2000s by a US stock, returning 208,333,233.3%.

ASSET	DECADE	% RETURN
XTI Aerospace (XTIA)	2000s	208,333,233.31%
Seanergy Maritime (SHIP)	2000s	7,067,229.62%
Flotek Industries (FTK)	2000s	2,679,900%
Epsilon Energy (EPSN)	2000s	2,464,500%
Trxade (MEDS)	2000s	1,291,853.45%
Natwest (NWG)	2000s	1,039,983.33%
Hirequest (HQI)	2000s	954,600%
Opus Genetics (IRD)	2000s	326,300%
Perspective Therapeutics (CATX)	2000s	296,566.67%
Alaunos Therapeutics (TCRT)	2000s	109,529.63%
Hudbay Minerals (HBM)	2000s	64,616.3%
Gulf Resources (GURE)	2000s	58,200%
Golden Minerals (AUMN)	2000s	48,400%
QXO (QXO)	2000s	43,353.66%
Know Labs (KNW)	2000s	26,617.56%
TherapeuticsMD (TXMD)	2000s	19,503.88%
Companhia Energetica de Minas Gerais CEMIG Pref ADR (CIG)	2000s	17,355%
Ainos (AIMD)	2000s	15,428.85%
TG Therapeutics (TGTX)	2000s	13,962.5%
Frontline (FRO)	2000s	12,614.11%
Companhia Siderurgica Nacional ADR (SID)	2000s	12,543.98%
Houston American Energy (HUSA)	2000s	12,534.48%
Portage Biotech (PRTG)	2000s	11,786.79%
Broadwind Energy (BWEN)	2000s	9,608.39%
MEDIFAST (MED)	2000s	8,796.54%