Enphase Energy (ENPH) had the highest return between 2018 and 2021 by a US stock in the S&P 500 (GSPC), returning 7,554.4%.

ASSET	YEARS	% RETURN
Enphase Energy (ENPH)	2018-2021	7,554.39%
Tesla (TSLA)	2018-2021	1,593.56%
Advanced Micro Devices (AMD)	2018-2021	1,281%
Moderna (MRNA)	2018-2021	1,054.45%
DexCom (DXCM)	2018-2021	831.88%
Fortinet (FTNT)	2018-2021	721.3%
Generac (GNRC)	2018-2021	608.66%
EPAM Systems (EPAM)	2018-2021	521.12%
NVIDIA (NVDA)	2018-2021	506.46%
Chipotle Mexican Grill (CMG)	2018-2021	500.98%
Axon Enterprise (AXON)	2018-2021	492.01%
Zebra Technologies (ZBRA)	2018-2021	471.76%
Paycom Soft (PAYC)	2018-2021	415.96%
Lululemon Athletica (LULU)	2018-2021	406.34%
MSCI (MSCI)	2018-2021	399.67%
ServiceNow (NOW)	2018-2021	395.5%
Amun Bitwise Select 10 Large Cap Crypto ETP (KEYS)	2018-2021	392.86%
Blackstone (BX)	2018-2021	382.1%
West Pharmaceutical Services (WST)	2018-2021	381.36%
Deckers Outdoor (DECK)	2018-2021	362.92%
Carrier Global (CARR)	2018-2021	360.98%
Pool (POOL)	2018-2021	353.39%
Monolithic Power Systems (MPWR)	2018-2021	352.13%
Cadence Design Systems (CDNS)	2018-2021	343.69%
Match (MTCH)	2018-2021	341.12%