NVIDIA (NVDA) had the highest return between 2016 and 2017 by a US stock in the S&P 500 (GSPC), returning 507.4%.

ASSET	YEARS	% RETURN
NVIDIA (NVDA)	2016-2017	507.39%
Advanced Micro Devices (AMD)	2016-2017	271.12%
Texas Pacific Land Trust (TPL)	2016-2017	256.81%
Align Technology (ALGN)	2016-2017	241.88%
Take-Two Interactive Software (TTWO)	2016-2017	222.41%
Caesars Entertainment (CZR)	2016-2017	205.53%
Arista Networks (ANET)	2016-2017	202.61%
Micron Technology (MU)	2016-2017	197.32%
Freeport-McMoran Copper & Gold (FCX)	2016-2017	187.27%
Applied Materials (AMAT)	2016-2017	186.4%
Wynn Resorts (WYNN)	2016-2017	161.53%
Apollo Global Management LLC Class A (APO)	2016-2017	157.81%
FMC (FMC)	2016-2017	156.13%
Steel Dynamics (STLD)	2016-2017	154.5%
NRG Energy (NRG)	2016-2017	153.09%
Caterpillar (CAT)	2016-2017	152.75%
Best Buy (BBY)	2016-2017	145.99%
ONEOK (OKE)	2016-2017	144.34%
Lam Research (LRCX)	2016-2017	143.25%
United Rentals (URI)	2016-2017	141.75%
Albemarle (ALB)	2016-2017	139.05%
Nordson (NDSN)	2016-2017	135.48%
Match (MTCH)	2016-2017	133.14%
Copart (CPRT)	2016-2017	129.79%
Old Dominion Freight Line (ODFL)	2016-2017	126.5%