Constellation Energy (CEG) has had the highest return between 2022 and 2025 by a US stock with a market cap of $60B+, returning 484.2%.

ASSET	YEARS	% RETURN
Constellation Energy (CEG)	2022-2025	484.19%
MicroStrategy (MSTR)	2022-2025	439.15%
Palantir Technologies Inc Class A Common Stock (PLTR)	2022-2025	401.14%
NVIDIA (NVDA)	2022-2025	284.14%
GE Aerospace (GE)	2022-2025	220.68%
Petróleo Brasileiro SA - Petrobras (PBR.A)	2022-2025	199.34%
Broadcom (AVGO)	2022-2025	198.16%
Applovin (APP)	2022-2025	189.43%
GE Vernova LLC (GEV)	2022-2025	184.4%
Eli Lilly and (LLY)	2022-2025	183.45%
McKesson (MCK)	2022-2025	176.19%
Petroleo Brasileiro Petrobras SA ADR (PBR)	2022-2025	172.95%
Progressive (PGR)	2022-2025	172.33%
Banco Bilbao Viscaya Argentaria SA ADR (BBVA)	2022-2025	163.72%
Williams Companies (WMB)	2022-2025	152.87%
Spotify Technology (SPOT)	2022-2025	141.9%
Mitsubishi UFJ Financial Group Inc ADR (MUFG)	2022-2025	136.28%
Transdigm (TDG)	2022-2025	132.06%
Boston Scientific (BSX)	2022-2025	127.21%
T-Mobile US (TMUS)	2022-2025	125.17%
Vertex Pharmaceuticals (VRTX)	2022-2025	120.85%
Sumitomo Mitsui Financial (SMFG)	2022-2025	119.03%
Interactive Brokers (IBKR)	2022-2025	117.32%
Banco Santander SA ADR (SAN)	2022-2025	115.88%
Mizuho Financial (MFG)	2022-2025	113.54%