Vistra Energy (VST) has had the highest return between 2022 and 2025 by a US stock with a market cap of $40B+, returning 513.9%.

ASSET	YEARS	% RETURN
Vistra Energy (VST)	2022-2025	513.95%
Constellation Energy (CEG)	2022-2025	503.25%
MicroStrategy (MSTR)	2022-2025	452.11%
Palantir Technologies Inc Class A Common Stock (PLTR)	2022-2025	395.42%
Fair Isaac (FICO)	2022-2025	323.95%
Howmet Aerospace (HWM)	2022-2025	313.18%
Targa Resources (TRGP)	2022-2025	305.97%
NVIDIA (NVDA)	2022-2025	295.43%
Axon Enterprise (AXON)	2022-2025	257.6%
GE Aerospace (GE)	2022-2025	249.56%
Applovin (APP)	2022-2025	230.56%
Petroleo Brasileiro Petrobras SA ADR (PBR)	2022-2025	216.38%
Eli Lilly and (LLY)	2022-2025	214.99%
Broadcom (AVGO)	2022-2025	208.64%
Mitsubishi UFJ Financial Group Inc ADR (MUFG)	2022-2025	198.95%
Banco Bilbao Viscaya Argentaria SA ADR (BBVA)	2022-2025	195.72%
Petróleo Brasileiro SA - Petrobras (PBR.A)	2022-2025	194.34%
Energy Transfer (ET)	2022-2025	194.29%
GE Vernova LLC (GEV)	2022-2025	190.54%
Royal Caribbean Cruises (RCL)	2022-2025	180.07%
Progressive (PGR)	2022-2025	175.01%
McKesson (MCK)	2022-2025	171.84%
Sumitomo Mitsui Financial (SMFG)	2022-2025	171.67%
Mizuho Financial (MFG)	2022-2025	168.71%
Williams Companies (WMB)	2022-2025	167.12%