NVIDIA (NVDA) has had the highest return between 2017 and 2025 by a US stock with a market cap of $60B+, returning 3,846.4%.

ASSET	YEARS	% RETURN
NVIDIA (NVDA)	2017-2025	3,846.42%
Shopify Inc Class A Subordinate Voting Shares (SHOP)	2017-2025	1,832.76%
Tesla (TSLA)	2017-2025	1,585.07%
MicroStrategy (MSTR)	2017-2025	1,497.58%
Fortinet (FTNT)	2017-2025	1,472.81%
MercadoLibre (MELI)	2017-2025	1,224.18%
Eli Lilly and (LLY)	2017-2025	1,205.73%
Broadcom (AVGO)	2017-2025	1,111.17%
Arista Networks (ANET)	2017-2025	1,067.92%
ServiceNow (NOW)	2017-2025	925.31%
Cadence Design Systems (CDNS)	2017-2025	923.28%
Palantir Technologies Inc Class A Common Stock (PLTR)	2017-2025	837.8%
KLA-Tencor (KLAC)	2017-2025	825.24%
Apollo Global Management LLC Class A (APO)	2017-2025	821.63%
Progressive (PGR)	2017-2025	820.79%
Palo Alto Networks (PANW)	2017-2025	699.48%
Ferrari (RACE)	2017-2025	688.13%
Netflix (NFLX)	2017-2025	678.67%
Advanced Micro Devices (AMD)	2017-2025	666.2%
Cintas (CTAS)	2017-2025	666.03%
KKR (KKR)	2017-2025	657.26%
Sea (SE)	2017-2025	644.43%
Apple (AAPL)	2017-2025	635.51%
Transdigm (TDG)	2017-2025	628.89%
Costco Wholesale (COST)	2017-2025	624.37%