Vipshop (VIPS) had the highest return between 2010 and 2015 by a US stock with a market cap of $5B+, returning 2,444.9%.

ASSET	YEARS	% RETURN
Vipshop (VIPS)	2010-2015	2,444.88%
Regeneron Pharmaceuticals (REGN)	2010-2015	2,139.56%
Neurocrine Biosciences (NBIX)	2010-2015	1,942.24%
Jazz Pharmaceuticals (JAZZ)	2010-2015	1,643.92%
Nexstar Broadcasting (NXST)	2010-2015	1,418.38%
Cheniere Energy (LNG)	2010-2015	1,389.95%
Domino’s Pizza (DPZ)	2010-2015	1,363.15%
Netflix (NFLX)	2010-2015	1,342.12%
Lithia Motors (LAD)	2010-2015	1,281.39%
Tesla (TSLA)	2010-2015	1,163.18%
Incyte (INCY)	2010-2015	1,076.25%
Manhattan Associates (MANH)	2010-2015	987.88%
DexCom (DXCM)	2010-2015	897.56%
Ulta Beauty (ULTA)	2010-2015	872.8%
Alaska Air (ALK)	2010-2015	850.99%
Western Alliance Bancorporation (WAL)	2010-2015	821.83%
Constellation Brands Inc Class A (STZ)	2010-2015	795.84%
MarketAxess (MKTX)	2010-2015	788.99%
American Airlines (AAL)	2010-2015	786.97%
Tyler Technologies (TYL)	2010-2015	769.43%
Broadcom (AVGO)	2010-2015	760.76%
Dycom Industries (DY)	2010-2015	760.52%
Caesars Entertainment (CZR)	2010-2015	746.15%
U-Haul (UHAL)	2010-2015	729.02%
Genmab A-S (GMAB)	2010-2015	702.51%