Monster Beverage (MNST) had the highest return between 2001 and 2009 by a US stock with a market cap of $50B+, returning 7,960.5%.

ASSET	YEARS	% RETURN
Monster Beverage (MNST)	2001-2009	7,960.45%
NetEase (NTES)	2001-2009	4,714.48%
Apple (AAPL)	2001-2009	2,733.65%
Southern Copper (SCCO)	2001-2009	2,592.33%
Booking (BKNG)	2001-2009	2,547.49%
Intuitive Surgical (ISRG)	2001-2009	1,767.32%
Petroleo Brasileiro Petrobras SA ADR (PBR)	2001-2009	1,259.69%
BHP (BHP)	2001-2009	1,150.27%
Petróleo Brasileiro SA - Petrobras (PBR.A)	2001-2009	1,105.3%
Canadian Natural Resources (CNQ)	2001-2009	1,067.86%
Freeport-McMoran Copper & Gold (FCX)	2001-2009	1,061.51%
Itau Unibanco Banco (ITUB)	2001-2009	981%
Altria (MO)	2001-2009	891.02%
HDFC Bank Limited ADR (HDB)	2001-2009	853.75%
CME (CME)	2001-2009	834.6%
Amazon (AMZN)	2001-2009	750.64%
Gilead Sciences (GILD)	2001-2009	729.1%
ICICI Bank (IBN)	2001-2009	598.88%
Brookfield (BN)	2001-2009	580.77%
Netflix (NFLX)	2001-2009	580.56%
Canadian National Railway (CNI)	2001-2009	543.2%
Mastercard (MA)	2001-2009	542.77%
British American Tobacco (BTI)	2001-2009	523.73%
Alphabet Inc Class A (GOOGL)	2001-2009	519.93%
BlackRock (BLK)	2001-2009	509.47%