Monster Beverage (MNST) had the highest return between 2001 and 2008 by a US stock with a market cap of $50B+, returning 6,938.3%.

ASSET	YEARS	% RETURN
Monster Beverage (MNST)	2001-2008	6,938.29%
NetEase (NTES)	2001-2008	2,728.24%
Southern Copper (SCCO)	2001-2008	1,187.95%
Apple (AAPL)	2001-2008	1,047.68%
Gilead Sciences (GILD)	2001-2008	879.9%
Booking (BKNG)	2001-2008	792.76%
Intuitive Surgical (ISRG)	2001-2008	681.5%
Altria (MO)	2001-2008	606.08%
Petroleo Brasileiro Petrobras SA ADR (PBR)	2001-2008	577.88%
BHP (BHP)	2001-2008	576.78%
Canadian Natural Resources (CNQ)	2001-2008	544.4%
CME (CME)	2001-2008	468.86%
Petróleo Brasileiro SA - Petrobras (PBR.A)	2001-2008	459.68%
HDFC Bank Limited ADR (HDB)	2001-2008	420.26%
AutoZone (AZO)	2001-2008	393.7%
British American Tobacco (BTI)	2001-2008	385.98%
Itau Unibanco Banco (ITUB)	2001-2008	385.24%
Brookfield (BN)	2001-2008	355.11%
Canadian National Railway (CNI)	2001-2008	326.02%
Norfolk Southern (NSC)	2001-2008	284.31%
PACCAR (PCAR)	2001-2008	281.37%
Netflix (NFLX)	2001-2008	269.25%
Mastercard (MA)	2001-2008	257.64%
Freeport-McMoran Copper & Gold (FCX)	2001-2008	253.56%
ICICI Bank (IBN)	2001-2008	251.55%