Natwest (NWG) had the highest return between 2000 and 2010 by a US stock with a market cap of $1B+, returning 1,364,516.7%.

ASSET	YEARS	% RETURN
Natwest (NWG)	2000-2010	1,364,516.67%
Hudbay Minerals (HBM)	2000-2010	91,720.11%
QXO (QXO)	2000-2010	21,626.79%
Companhia Energetica de Minas Gerais CEMIG Pref ADR (CIG)	2000-2010	20,790%
Frontline (FRO)	2000-2010	18,508.35%
Companhia Siderurgica Nacional ADR (SID)	2000-2010	13,527.53%
Monster Beverage (MNST)	2000-2010	9,668.39%
Deckers Outdoor (DECK)	2000-2010	9,015.23%
BRF SA ADR (BRFS)	2000-2010	7,599.9%
Clean Harbors (CLH)	2000-2010	6,798.59%
Banco Bradesco SA ADR (BBD)	2000-2010	5,090.29%
Denison Mines (DNN)	2000-2010	4,588.94%
Southern Copper (SCCO)	2000-2010	3,423.83%
TG Therapeutics (TGTX)	2000-2010	3,275%
Amedisys (AMED)	2000-2010	3,148.64%
Middleby (MIDD)	2000-2010	3,031.89%
Ambev SA ADR (ABEV)	2000-2010	2,999.52%
HF Sinclair (DINO)	2000-2010	2,916.45%
Vale SA ADR (VALE)	2000-2010	2,819.64%
CarMax (KMX)	2000-2010	2,733.78%
Sociedad Quimica y Minera de Chile SA ADR B (SQM)	2000-2010	2,497.07%
Alamos Gold (AGI)	2000-2010	2,357.63%
Tractor Supply (TSCO)	2000-2010	2,335.11%
RPC (RES)	2000-2010	2,258.11%
Alliance Resource Partners (ARLP)	2000-2010	2,219.04%