Know Labs (KNW) had the highest return between 2000 and 2008 by a US stock, returning 534,224.4%.

ASSET	YEARS	% RETURN
Know Labs (KNW)	2000-2008	534,224.43%
Perspective Therapeutics (CATX)	2000-2008	66,566.67%
Frontline (FRO)	2000-2008	19,308.26%
Companhia Energetica de Minas Gerais CEMIG Pref ADR (CIG)	2000-2008	9,947.37%
TherapeuticsMD (TXMD)	2000-2008	7,439.95%
Houston American Energy (HUSA)	2000-2008	6,731.48%
Monster Beverage (MNST)	2000-2008	6,165.02%
Gulf Resources (GURE)	2000-2008	5,900%
Broadwind Energy (BWEN)	2000-2008	5,300.22%
Clean Harbors (CLH)	2000-2008	5,105.12%
Ainos (AIMD)	2000-2008	4,924.04%
Companhia Siderurgica Nacional ADR (SID)	2000-2008	4,291.4%
Amedisys (AMED)	2000-2008	3,908.92%
Oramed Pharmaceuticals (ORMP)	2000-2008	3,134.28%
Dmc Global (BOOM)	2000-2008	3,047.74%
Deckers Outdoor (DECK)	2000-2008	2,943.35%
BRF SA ADR (BRFS)	2000-2008	2,860.41%
Team (TISI)	2000-2008	2,854.67%
BP Prudhoe Bay Royalty Trust (BPT)	2000-2008	2,805.39%
American Vanguard (AVD)	2000-2008	1,976.56%
FTI Consulting (FCN)	2000-2008	1,910.62%
RadNet (RDNT)	2000-2008	1,870.59%
Banco Bradesco SA ADR (BBD)	2000-2008	1,817.93%
Altria (MO)	2000-2008	1,730.19%
Cal-Maine Foods (CALM)	2000-2008	1,680.24%