OPTIMIZERx (OPRX) had the highest return between 1999 and 2000 by a US stock, returning 1,600%.

ASSET	YEARS	% RETURN
OPTIMIZERx (OPRX)	1999-2000	1,600%
Myriad Genetics (MYGN)	1999-2000	1,554.98%
FuelCell Energy (FCEL)	1999-2000	1,409.61%
Laboratory Corporation of America (LH)	1999-2000	1,180.12%
Qualcomm (QCOM)	1999-2000	1,153.85%
Applied DNA Sciences (APDN)	1999-2000	1,100%
Check Point Software Technologies (CHKP)	1999-2000	1,061.41%
Ciena (CIEN)	1999-2000	969.96%
Innodata (INOD)	1999-2000	945.63%
Suzano Papel e Celulose SA ADR (SUZ)	1999-2000	881.29%
Titan Pharmaceuticals (TTNP)	1999-2000	875.72%
Patterson-UTI Energy (PTEN)	1999-2000	803.03%
AYRO (AYRO)	1999-2000	725%
Biogen (BIIB)	1999-2000	705.57%
Quest Diagnostics (DGX)	1999-2000	699.99%
Algorhythm (RIME)	1999-2000	642.92%
Juniper Networks (JNPR)	1999-2000	620.36%
BlackBerry (BB)	1999-2000	592.82%
Aptose Biosciences (APTO)	1999-2000	580.15%
Amtech Systems (ASYS)	1999-2000	540%
Forward Air (FWRD)	1999-2000	498.99%
Sono-Tek (SOTK)	1999-2000	476.92%
EMCORE (EMKR)	1999-2000	441.01%
NetApp (NTAP)	1999-2000	440.53%
Regeneron Pharmaceuticals (REGN)	1999-2000	403.79%