Tectonic Therapeutic (TECX) has had the highest return this decade by a US stock, returning 4,405,900%.

ASSET	DECADE	% RETURN
Tectonic Therapeutic (TECX)	2020s	4,405,900%
Gorilla Technology (GRRR)	2020s	1,273,400%
Cadrenal Therapeutics, Inc Common Stock (CVKD)	2020s	965,900%
MGO Global Inc Common Stock (MGOL)	2020s	279,900%
AppTech Payments Corp Warrant (APCXW)	2020s	159,900%
Asset Entities Inc Class B Common Stock (ASST)	2020s	127,966.67%
Jianzhi Education Technology Group Company Limited American Depositary Shares (JZ)	2020s	99,900%
authID (AUID)	2020s	81,306.25%
Zhihu Inc ADR (ZH)	2020s	49,626.03%
Digihost Technology (DGHI)	2020s	25,614.29%
Applied Digital (APLD)	2020s	18,522.69%
Ainos (AIMD)	2020s	10,902.5%
XORTX Therapeutics (XRTX)	2020s	9,639.13%
Azitra (AZTR)	2020s	6,957.14%
Agape ATP Corporation Common Stock (ATPC)	2020s	6,700%
Digital Brands (DBGIW)	2020s	5,061.29%
ZyVersa Therapeutics (ZVSA)	2020s	4,312.81%
Kaival Brands Innovations (KAVL)	2020s	4,205.5%
CPI Card (PMTS)	2020s	3,418.89%
Innodata (INOD)	2020s	3,387.72%
Bone Biologics Corp Warrants (BBLGW)	2020s	3,162.91%
Perpetua Resources (PPTA)	2020s	2,411.73%
SoundHound AI (SOUNW)	2020s	2,394.1%
Alpha Metallurgical Resources (AMR)	2020s	2,294.75%
Limbach (LMB)	2020s	2,284.41%