Fresh2 (FRES) had the highest return between 2019 and 2021 by a US stock, returning 433,292.5%.

ASSET	YEARS	% RETURN
Fresh2 (FRES)	2019-2021	433,292.54%
Oxbridge Re Holdings Equity Warrant (OXBRW)	2019-2021	53,563.64%
Applied Digital (APLD)	2019-2021	37,647.75%
Ainos (AIMD)	2019-2021	23,460.21%
NAYA Biosciences (NAYA)	2019-2021	12,707.69%
374Water Inc Common Stock (SCWO)	2019-2021	5,600%
Iveda Solutions (IVDA)	2019-2021	5,541.03%
Cassava Sciences (SAVA)	2019-2021	5,041.18%
Accolade (ACCD)	2019-2021	4,692.73%
Golden Matrix (GMGI)	2019-2021	4,180%
Sobr Safe (SOBR)	2019-2021	3,958.94%
Enphase Energy (ENPH)	2019-2021	3,851.19%
Nuvve (NVVEW)	2019-2021	3,583.33%
Inotiv (NOTV)	2019-2021	3,238.89%
Digital Turbine (APPS)	2019-2021	3,196.76%
Graf Industrial Corp Warrants (each warrant exercisable for one-half of one share of common stock each at an exercise price of $1150 per share) (GRAF.WT)	2019-2021	3,121.34%
Fulgent Genetics (FLGT)	2019-2021	3,073.19%
Centrus Energy (LEU)	2019-2021	2,943.29%
Firefly Neuroscience (AIFF)	2019-2021	2,257.14%
Aspen Aerogels (ASPN)	2019-2021	2,237.56%
Plug Power (PLUG)	2019-2021	2,176.61%
Sitime (SITM)	2019-2021	2,150.31%
Celsius (CELH)	2019-2021	2,099.71%
Marathon Digital (MARA)	2019-2021	2,061.84%
Integra Resources (ITRG)	2019-2021	2,035.05%