Indivior PLC Ordinary Shares (INDV) had the highest return in 2022 by a US stock with a market cap of $100M+, returning 520.4%.

ASSET	YEAR	% RETURN
Indivior PLC Ordinary Shares (INDV)	2022	520.37%
Kolibri Global Energy Inc Common stock (KGEI)	2022	391.67%
Ardmore Shpng (ASC)	2022	328.87%
Scorpio Tankers (STNG)	2022	315.75%
Target Hospitality (TH)	2022	313.66%
Hallador Energy (HNRG)	2022	306.1%
Torm PLC Class A (TRMD)	2022	294.68%
Verona Pharma PLC ADR (VRNA)	2022	284.83%
HighPeak Energy (HPKEW)	2022	245.96%
Tidewater (TDW)	2022	244.39%
Madrigal Pharmaceuticals (MDGL)	2022	238.09%
TransMedics (TMDX)	2022	221.29%
PBF Energy (PBF)	2022	211.45%
Vista Oil Gas ADR (VIST)	2022	195.47%
Rhythm Pharmaceuticals (RYTM)	2022	191.2%
Astria Therapeutics (ATXS)	2022	179.36%
Amplify Energy (AMPY)	2022	179.05%
Teekay Tankers (TNK)	2022	177.32%
ADMA Biologics (ADMA)	2022	177.14%
Catalyst Pharmaceuticals (CPRX)	2022	173.93%
SEACOR Marine (SMHI)	2022	172.62%
Permian Basin Royalty Trust (PBT)	2022	166.23%
Sigma Lithium Resources (SGML)	2022	165.98%
Transportadora de Gas del Sur SA ADR (TGS)	2022	163.98%
International Seaways (INSW)	2022	159.01%