Natwest (NWG) had the highest return between 1992 and 2010 by a US stock with a market cap of $1B+, returning 1,364,516.7%.

ASSET	YEARS	% RETURN
Natwest (NWG)	1992-2010	1,364,516.67%
Royal Gold (RGLD)	1992-2010	192,592.89%
Hudbay Minerals (HBM)	1992-2010	91,720.11%
United Community Banks (UCB)	1992-2010	36,417.17%
QXO (QXO)	1992-2010	21,626.79%
Companhia Siderurgica Nacional ADR (SID)	1992-2010	21,497.58%
Middleby (MIDD)	1992-2010	21,348.17%
Companhia Energetica de Minas Gerais CEMIG Pref ADR (CIG)	1992-2010	20,790%
Frontline (FRO)	1992-2010	18,508.35%
Monster Beverage (MNST)	1992-2010	18,439.15%
Cognizant Technology Solutions Corp Class A (CTSH)	1992-2010	17,488.28%
Coherent (COHR)	1992-2010	12,261.72%
Diodes (DIOD)	1992-2010	12,052.18%
AAON (AAON)	1992-2010	11,266.51%
Semtech (SMTC)	1992-2010	9,558.7%
Oracle (ORCL)	1992-2010	8,778.3%
Bausch Health Companies (BHC)	1992-2010	8,304.63%
BRF SA ADR (BRFS)	1992-2010	7,599.85%
Amazon (AMZN)	1992-2010	7,283.1%
Qualcomm (QCOM)	1992-2010	7,256.11%
Expeditors International of Washington (EXPD)	1992-2010	6,853.69%
Gerdau SA ADR (GGB)	1992-2010	6,647.23%
Microchip Technology (MCHP)	1992-2010	6,598.74%
Mueller Industries (MLI)	1992-2010	6,493.31%
Jack Henry & Associates (JKHY)	1992-2010	5,965.06%