AppTech Payments Corp Warrant (APCXW) had the highest return between 2021 and 2022 by a US stock, returning 140,200%.

ASSET	YEARS	% RETURN
AppTech Payments Corp Warrant (APCXW)	2021-2022	140,200%
Destination XL (DXLG)	2021-2022	2,476.34%
Zivo Bioscience (ZIVO)	2021-2022	1,544.74%
Indivior PLC Ordinary Shares (INDV)	2021-2022	1,499.26%
Impact BioMedical (IBO)	2021-2022	1,464.01%
Ainos (AIMD)	2021-2022	1,450%
Alpha Metallurgical Resources (AMR)	2021-2022	1,245.02%
Sigma Lithium Resources (SGML)	2021-2022	1,028.8%
Peabody Energy (BTU)	2021-2022	973.99%
LakeShore Biopharma (LSB)	2021-2022	955.26%
Obsidian Energy (OBE)	2021-2022	891.04%
Hudson Technologies (HDSN)	2021-2022	854.72%
Target Hospitality (TH)	2021-2022	846.25%
Empire Petroleum (EP)	2021-2022	831.85%
Consol Energy (CEIX)	2021-2022	829.62%
Birks (BGI)	2021-2022	822.2%
Weatherford International (WFRD)	2021-2022	757.96%
Permian Basin Royalty Trust (PBT)	2021-2022	750.3%
Baytex Energy (BTE)	2021-2022	719.98%
Applied Digital (APLD)	2021-2022	717.78%
CPI Card (PMTS)	2021-2022	713.53%
Aehr Test Systems (AEHR)	2021-2022	704%
CVR Partners (UAN)	2021-2022	681.7%
Kolibri Global Energy Inc Common stock (KGEI)	2021-2022	637.5%
Hudson Acquisition I Corp Right (HUDAR)	2021-2022	628.57%