Verona Pharma PLC ADR (VRNA) had the highest return in December 2021 by a US stock with a market cap of $2B+, returning 39.1%.

ASSET	MONTH	% RETURN
Verona Pharma PLC ADR (VRNA)	December 2021	39.13%
Hagerty (HGTY)	December 2021	38.88%
Roivant Sciences (ROIV)	December 2021	34.04%
Advantage Solutions (ADVWW)	December 2021	32.8%
Bellring Brands LLC (BRBR)	December 2021	31.47%
TG Therapeutics (TGTX)	December 2021	30.58%
Jackson Financial (JXN)	December 2021	30.27%
Embraer SA ADR (ERJ)	December 2021	28.07%
Alpha Metallurgical Resources (AMR)	December 2021	27.8%
Intracellular Th (ITCI)	December 2021	27.5%
Laureate Education (LAUR)	December 2021	26.53%
Ciena (CIEN)	December 2021	25.85%
Fortress Transp & Infra Inv (FTAI)	December 2021	25.79%
Braskem SA Class A (BAK)	December 2021	25.71%
Pampa Energia SA ADR (PAM)	December 2021	24.95%
argenx NV ADR (ARGX)	December 2021	24.78%
Alcoa (AA)	December 2021	24.41%
Trump Media & Technology (DJT)	December 2021	24.05%
ACADIA Pharmaceuticals (ACAD)	December 2021	22.78%
Companhia de Saneamento Basico do Estado de Sao Paulo SABESP ADR (SBS)	December 2021	22.74%
Alliance Resource Partners (ARLP)	December 2021	22.48%
Endeavor (EDR)	December 2021	22.25%
Merus (MRUS)	December 2021	21.79%
Godaddy (GDDY)	December 2021	21.75%
Halozyme Therapeutics (HALO)	December 2021	21.59%