Crown Electrokinetics (CRKN) had the highest return in 2021 by a micro-cap US stock, returning 4,766,925.1%.

ASSET	YEAR	% RETURN
Crown Electrokinetics (CRKN)	2021	4,766,925.09%
A2Z Smart Technologies (AZ)	2021	1,592,547.06%
XORTX Therapeutics (XRTX)	2021	1,229,900%
authID (AUID)	2021	634,024.29%
Connexa Sports Technologies (YYAI)	2021	152,788.89%
KWESST Micro Systems Inc Common Stock (KWE)	2021	68,499.72%
Ainos (AIMD)	2021	31,400%
Sobr Safe (SOBR)	2021	31,173.13%
Draganfly (DPRO)	2021	5,818.66%
Kaival Brands Innovations (KAVL)	2021	3,538.37%
Destination XL (DXLG)	2021	2,067.94%
High Tide (HITI)	2021	2,022.88%
Zivo Bioscience (ZIVO)	2021	1,788.16%
Electra Battery Materials (ELBM)	2021	1,254.13%
LakeShore Biopharma (LSB)	2021	923.16%
Empire Petroleum (EP)	2021	814.42%
Greenwave Technology Solutions Inc Common Stock (GWAV)	2021	683.33%
Cerberus Cyber Sentinel (CISO)	2021	584.21%
BriaCell Therapeutics (BCTXW)	2021	560.56%
Cassava Sciences (SAVA)	2021	538.89%
Sangoma Technologies (SANG)	2021	513.09%
Vertex Energy (VTNR)	2021	499.21%
Mega Matrix (MPU)	2021	479.19%
Birks (BGI)	2021	464.02%
Imperial Petroleum (IMPP)	2021	434.93%

Micro-cap stocks are treated as having a market cap of <= $300M.