Monster Beverage (MNST) had the highest return between 2005 and 2008 by a large-cap US stock, returning 617.4%.

ASSET	YEARS	% RETURN
Monster Beverage (MNST)	2005-2008	617.38%
First Solar (FSLR)	2005-2008	463.1%
Illumina (ILMN)	2005-2008	453.08%
Banco Bradesco SA ADR (BBD)	2005-2008	433.74%
Clean Harbors (CLH)	2005-2008	317.37%
Agnico Eagle Mines (AEM)	2005-2008	279.71%
Credicorp (BAP)	2005-2008	258.04%
Mastercard (MA)	2005-2008	257.63%
Ambev SA ADR (ABEV)	2005-2008	237.23%
Alnylam Pharmaceuticals (ALNY)	2005-2008	222.43%
Intuitive Surgical (ISRG)	2005-2008	217.32%
Booking (BKNG)	2005-2008	210.5%
CF Industries (CF)	2005-2008	206.07%
Southern Copper (SCCO)	2005-2008	195.59%
Gilead Sciences (GILD)	2005-2008	187.79%
Royal Gold (RGLD)	2005-2008	185.17%
Suzano Papel e Celulose SA ADR (SUZ)	2005-2008	184.98%
Petroleo Brasileiro Petrobras SA ADR (PBR)	2005-2008	184.23%
Vertex Pharmaceuticals (VRTX)	2005-2008	183.93%
Biomarin Pharmaceutical (BMRN)	2005-2008	178.56%
Kinross Gold (KGC)	2005-2008	166.17%
Petróleo Brasileiro SA - Petrobras (PBR.A)	2005-2008	166.03%
Apple (AAPL)	2005-2008	163.52%
Quanta Services (PWR)	2005-2008	148.43%
Rogers Communications (RCI)	2005-2008	141.34%

Large-cap stocks are treated as having a market cap of $10B+.