Super Micro Computer (SMCI) has had the highest return between 2022 and 2024 by a large-cap US stock, returning 971.5%.

ASSET	YEARS	% RETURN
Super Micro Computer (SMCI)	2022-2024	971.51%
Summit Therapeutics (SMMT)	2022-2024	669.97%
Constellation Energy (CEG)	2022-2024	619.37%
Fortress Transp & Infra Inv (FTAI)	2022-2024	565.23%
YPF Sociedad Anonima (YPF)	2022-2024	546.23%
Vistra Energy (VST)	2022-2024	487.09%
Vaxcyte (PCVX)	2022-2024	380.76%
Fair Isaac (FICO)	2022-2024	364.6%
TechnipFMC (FTI)	2022-2024	358.27%
NVIDIA (NVDA)	2022-2024	352.84%
Vertiv (VRT)	2022-2024	345.32%
Comfort Systems USA (FIX)	2022-2024	323.61%
Sprouts Farmers Market LLC (SFM)	2022-2024	291.24%
MicroStrategy (MSTR)	2022-2024	286.1%
SharkNinja (SN)	2022-2024	265.56%
New Oriental Education & Technology (EDU)	2022-2024	262.27%
MakeMyTrip (MMYT)	2022-2024	260.68%
EMCOR (EME)	2022-2024	256.58%
Eli Lilly and (LLY)	2022-2024	249.35%
Targa Resources (TRGP)	2022-2024	238.13%
Howmet Aerospace (HWM)	2022-2024	227.34%
GE Aerospace (GE)	2022-2024	226.2%
CAVA (CAVA)	2022-2024	218.21%
Parsons (PSN)	2022-2024	218.13%
Petroleo Brasileiro Petrobras SA ADR (PBR)	2022-2024	206.46%

Large-cap stocks are treated as having a market cap of $10B+.