First Solar (FSLR) had the highest return in Q3 2022 by a large-cap US stock, returning 95.7%.

ASSET	QUARTER	% RETURN
First Solar (FSLR)	Q3 2022	95.72%
YPF Sociedad Anonima (YPF)	Q3 2022	90.49%
Sarepta Therapeutics (SRPT)	Q3 2022	48.24%
Constellation Energy (CEG)	Q3 2022	46.93%
Trade Desk (TTD)	Q3 2022	41.82%
Nutanix (NTNX)	Q3 2022	41.6%
Advanced Drainage Systems (WMS)	Q3 2022	39.35%
Dick’s Sporting Goods (DKS)	Q3 2022	39.06%
Paylocity Holdng (PCTY)	Q3 2022	38.85%
Alnylam Pharmaceuticals (ALNY)	Q3 2022	38.04%
Super Micro Computer (SMCI)	Q3 2022	37.4%
Joint Stock Company Kaspikz American Depository Shares (KSPI)	Q3 2022	37.31%
Coinbase Global (COIN)	Q3 2022	34.38%
Netflix (NFLX)	Q3 2022	33.4%
Aspen Technology (AZPN)	Q3 2022	30.05%
Biogen (BIIB)	Q3 2022	30.01%
Petroleo Brasileiro Petrobras SA ADR (PBR)	Q3 2022	29.2%
Petróleo Brasileiro SA - Petrobras (PBR.A)	Q3 2022	29%
DraftKings (DKNG)	Q3 2022	28.85%
MercadoLibre (MELI)	Q3 2022	28.81%
Albemarle (ALB)	Q3 2022	28.73%
Toast (TOST)	Q3 2022	28.71%
Pinterest (PINS)	Q3 2022	28.37%
Uber Technologies (UBER)	Q3 2022	28.02%
Cardinal Health (CAH)	Q3 2022	27.99%

Large-cap stocks are treated as having a market cap of $10B+.