Monster Beverage (MNST) had the highest return between 2003 and 2007 by a large-cap US stock, returning 8,307.3%.

ASSET	YEARS	% RETURN
Monster Beverage (MNST)	2003-2007	8,307.29%
Cheniere Energy (LNG)	2003-2007	4,921.4%
Deckers Outdoor (DECK)	2003-2007	4,584.28%
Axon Enterprise (AXON)	2003-2007	4,163.7%
ArcelorMittal SA ADR (MT)	2003-2007	4,040.89%
Banco Bradesco SA ADR (BBD)	2003-2007	4,006.51%
Apple (AAPL)	2003-2007	2,659.72%
Intuitive Surgical (ISRG)	2003-2007	2,526.15%
Williams Companies (WMB)	2003-2007	2,493.76%
Vale SA ADR (VALE)	2003-2007	2,112.67%
Southern Copper (SCCO)	2003-2007	2,042.14%
Petroleo Brasileiro Petrobras SA ADR (PBR)	2003-2007	1,997.36%
Petróleo Brasileiro SA - Petrobras (PBR.A)	2003-2007	1,945.3%
Akamai Technologies (AKAM)	2003-2007	1,822.22%
Illumina (ILMN)	2003-2007	1,637.79%
CME (CME)	2003-2007	1,530.05%
U-Haul (UHAL)	2003-2007	1,377.47%
America Movil SAB de CV ADR (AMX)	2003-2007	1,273.97%
Tenaris SA ADR (TS)	2003-2007	1,237.48%
Itau Unibanco Banco (ITUB)	2003-2007	1,209.66%
GameStop (GME)	2003-2007	1,167.54%
Booking (BKNG)	2003-2007	1,081.7%
Hologic (HOLX)	2003-2007	1,020.65%
First Solar (FSLR)	2003-2007	990.37%
Companhia de Saneamento Basico do Estado de Sao Paulo SABESP ADR (SBS)	2003-2007	935.14%

Large-cap stocks are treated as having a market cap of $10B+.