GameStop (GME) had the highest return between 2020 and 2022 by a large-cap US stock, returning 1,102.6%.

ASSET	YEARS	% RETURN
GameStop (GME)	2020-2022	1,102.61%
Antero Resources (AR)	2020-2022	976.04%
Moderna (MRNA)	2020-2022	817.83%
Tesla (TSLA)	2020-2022	335.27%
BioNTech SE (BNTX)	2020-2022	325.76%
Futu (FUTU)	2020-2022	288.25%
Carrier Global (CARR)	2020-2022	256.43%
Quanta Services (PWR)	2020-2022	250.24%
Sociedad Quimica y Minera de Chile SA ADR B (SQM)	2020-2022	246.76%
Super Micro Computer (SMCI)	2020-2022	244.23%
Texas Pacific Land Trust (TPL)	2020-2022	219.32%
EQT (EQT)	2020-2022	215.32%
United Therapeutics (UTHR)	2020-2022	214.76%
TFI International (TFII)	2020-2022	212.21%
Steel Dynamics (STLD)	2020-2022	206.53%
Albemarle (ALB)	2020-2022	204.45%
Freeport-McMoran Copper & Gold (FCX)	2020-2022	192.58%
Eli Lilly and (LLY)	2020-2022	191.36%
BJs Wholesale Club (BJ)	2020-2022	187.15%
Devon Energy (DVN)	2020-2022	186.01%
United Microelectronics (UMC)	2020-2022	181.57%
McKesson (MCK)	2020-2022	176.65%
Dick’s Sporting Goods (DKS)	2020-2022	171.15%
Tractor Supply (TSCO)	2020-2022	170.85%
Summit Therapeutics (SMMT)	2020-2022	165.63%

Large-cap stocks are treated as having a market cap of $10B+.