Soleno Therapeutics (SLNO) had the highest return between 2023 and 2024 by a mid-cap US stock, returning 2,050.7%.

ASSET	YEARS	% RETURN
Soleno Therapeutics (SLNO)	2023-2024	2,050.72%
Rigetti Computing (RGTI)	2023-2024	1,934.67%
SoundHound AI (SOUN)	2023-2024	1,033.71%
GeneDx (WGS)	2023-2024	762.63%
Terawulf (WULF)	2023-2024	744.78%
Iris Energy (IREN)	2023-2024	649.62%
Banco Macro SA B ADR (BMA)	2023-2024	611.42%
Powell Industries (POWL)	2023-2024	544.7%
Abercrombie & Fitch (ANF)	2023-2024	543.16%
BBVA Banco Frances SA ADR (BBAR)	2023-2024	510.76%
SkyWest (SKYW)	2023-2024	496.37%
Modine Manufacturing (MOD)	2023-2024	475.91%
IES (IESC)	2023-2024	469.29%
D-Wave Quantum (QBTS)	2023-2024	460%
Oscar Health (OSCR)	2023-2024	437.6%
Nextnav Acquisition (NN)	2023-2024	427.46%
Centessa Pharmaceuticals PLC ADR (CNTA)	2023-2024	420.19%
Empresa Distribuidora y Comercializadora Norte SA ADR (EDN)	2023-2024	416.99%
MoonLake Immunotherapeutics (MLTX)	2023-2024	410.85%
Sterling Construction (STRL)	2023-2024	408.14%
Cellebrite DI (CLBT)	2023-2024	401.82%
Archer Aviation (ACHR)	2023-2024	394.92%
Hut 8 Corp Common Stock (HUT)	2023-2024	380.31%
Marathon Digital (MARA)	2023-2024	379.47%
United States Lime & Minerals (USLM)	2023-2024	374.79%

Mid-cap stocks are treated as having a market cap between $2B and $10B.