Ferguson (FERG) had the highest return between 2010 and 2019 by a large-cap US stock, returning 58,898.8%.

ASSET	YEARS	% RETURN
Ferguson (FERG)	2010-2019	58,898.82%
Netflix (NFLX)	2010-2019	3,979.61%
Domino's Pizza Inc Common Stock (DPZ)	2010-2019	3,916.78%
Neurocrine Biosciences (NBIX)	2010-2019	3,780.51%
Texas Pacific Land Trust (TPL)	2010-2019	2,630.95%
DexCom (DXCM)	2010-2019	2,564.31%
Cheniere Energy (LNG)	2010-2019	2,342.72%
Transdigm (TDG)	2010-2019	2,150.87%
Tesla (TSLA)	2010-2019	2,101.68%
Broadcom (AVGO)	2010-2019	1,979.59%
Fair Isaac (FICO)	2010-2019	1,675.4%
United Rentals (URI)	2010-2019	1,581.15%
Axon Enterprise (AXON)	2010-2019	1,543.05%
HEICO (HEI.A)	2010-2019	1,521.75%
Regeneron Pharmaceuticals (REGN)	2010-2019	1,449.01%
Align Technology (ALGN)	2010-2019	1,445.93%
XPO Logistics (XPO)	2010-2019	1,432.39%
Shopify Inc Class A Subordinate Voting Shares (SHOP)	2010-2019	1,429.15%
Lululemon Athletica (LULU)	2010-2019	1,400.45%
Tyler Technologies (TYL)	2010-2019	1,396.36%
Paycom Soft (PAYC)	2010-2019	1,379.11%
Old Dominion Freight Line (ODFL)	2010-2019	1,311.9%
CoStar (CSGP)	2010-2019	1,311.75%
Charter Communications (CHTR)	2010-2019	1,285.94%
NVIDIA (NVDA)	2010-2019	1,280.25%

Large-cap stocks are treated as having a market cap of $10B+.