Monster Beverage (MNST) had the highest return between 2003 and 2007 by a large-cap US stock, returning 8,307.3%.

ASSET	YEARS	% RETURN
Monster Beverage (MNST)	2003-2007	8,307.29%
Cheniere Energy (LNG)	2003-2007	4,921.4%
Deckers Outdoor (DECK)	2003-2007	4,584.28%
Axon Enterprise (AXON)	2003-2007	4,163.7%
ArcelorMittal SA ADR (MT)	2003-2007	4,068.74%
Banco Bradesco SA ADR (BBD)	2003-2007	4,039.38%
Apple (AAPL)	2003-2007	2,660.18%
Intuitive Surgical (ISRG)	2003-2007	2,526.15%
Williams Companies (WMB)	2003-2007	2,486.41%
Vale SA ADR (VALE)	2003-2007	2,113.23%
Southern Copper (SCCO)	2003-2007	2,049.09%
Petroleo Brasileiro Petrobras SA ADR (PBR)	2003-2007	1,997.57%
Petróleo Brasileiro SA - Petrobras (PBR.A)	2003-2007	1,945.1%
Akamai Technologies (AKAM)	2003-2007	1,822.22%
Illumina (ILMN)	2003-2007	1,637.79%
CME (CME)	2003-2007	1,530.04%
U-Haul (UHAL)	2003-2007	1,377.47%
America Movil SAB de CV ADR (AMX)	2003-2007	1,273.97%
Tenaris SA ADR (TS)	2003-2007	1,237.48%
Itau Unibanco Banco (ITUB)	2003-2007	1,193.79%
GameStop (GME)	2003-2007	1,167.54%
Booking (BKNG)	2003-2007	1,081.7%
Hologic (HOLX)	2003-2007	1,020.65%
First Solar (FSLR)	2003-2007	990.37%
Cameco (CCJ)	2003-2007	933.67%

Large-cap stocks are treated as having a market cap of $10B+.