Sarepta Therapeutics (SRPT) had the highest return in Q3 2016 by a large-cap US stock, returning 221.9%.

ASSET	QUARTER	% RETURN
Sarepta Therapeutics (SRPT)	Q3 2016	221.86%
Twilio (TWLO)	Q3 2016	74.09%
Seagate Technology (STX)	Q3 2016	62.04%
Permian Resources (PR)	Q3 2016	61.54%
Danaher (DHR)	Q3 2016	58.96%
MakeMyTrip (MMYT)	Q3 2016	58.71%
Penske Automotive (PAG)	Q3 2016	53.84%
Williams Companies (WMB)	Q3 2016	50.94%
Centrais Electricas Brasileiras (EBR)	Q3 2016	50.26%
Liberty Media Corporation Series A Liberty Formula One Common Stock (FWONA)	Q3 2016	49.37%
Liberty Media Corporation Series C Liberty Formula One Common Stock (FWONK)	Q3 2016	48.34%
Insmed (INSM)	Q3 2016	47.56%
NetApp (NTAP)	Q3 2016	47.06%
NVIDIA (NVDA)	Q3 2016	46.83%
Texas Pacific Land Trust (TPL)	Q3 2016	43.55%
Petróleo Brasileiro SA - Petrobras (PBR.A)	Q3 2016	42.78%
Wix (WIX)	Q3 2016	42.72%
Logitech International (LOGI)	Q3 2016	41.89%
Micron Technology (MU)	Q3 2016	41.34%
ON Semiconductor (ON)	Q3 2016	40.96%
eBay (EBAY)	Q3 2016	40.42%
XPO Logistics (XPO)	Q3 2016	40.34%
Marvell Technology (MRVL)	Q3 2016	40.33%
STMicroelectronics NV ADR (STM)	Q3 2016	39.91%
Nutanix (NTNX)	Q3 2016	39.62%

Large-cap stocks are treated as having a market cap of $10B+.