Monster Beverage (MNST) had the highest return between 2003 and 2008 by a large-cap US stock, returning 6,264.9%.

ASSET	YEARS	% RETURN
Monster Beverage (MNST)	2003-2008	6,264.92%
Deckers Outdoor (DECK)	2003-2008	2,312.83%
Banco Bradesco SA ADR (BBD)	2003-2008	1,981.14%
Axon Enterprise (AXON)	2003-2008	1,464.44%
Illumina (ILMN)	2003-2008	1,427.82%
ArcelorMittal SA ADR (MT)	2003-2008	1,263.21%
Bancolombia SA ADR (CIB)	2003-2008	1,194.87%
Apple (AAPL)	2003-2008	1,089.12%
Sociedad Quimica y Minera de Chile SA ADR B (SQM)	2003-2008	1,043.44%
Williams Companies (WMB)	2003-2008	968.15%
Southern Copper (SCCO)	2003-2008	960.98%
Intuitive Surgical (ISRG)	2003-2008	932.49%
Petroleo Brasileiro Petrobras SA ADR (PBR)	2003-2008	829.37%
Petróleo Brasileiro SA - Petrobras (PBR.A)	2003-2008	811.08%
Alamos Gold (AGI)	2003-2008	774.34%
Vale SA ADR (VALE)	2003-2008	744.61%
Akamai Technologies (AKAM)	2003-2008	738.33%
Itau Unibanco Banco (ITUB)	2003-2008	680.28%
U-Haul (UHAL)	2003-2008	676.74%
Elbit Systems (ESLT)	2003-2008	663.28%
Booking (BKNG)	2003-2008	657.72%
NetEase (NTES)	2003-2008	654.96%
America Movil SAB de CV ADR (AMX)	2003-2008	600.57%
Rogers Communications (RCI)	2003-2008	578.77%
YPF Sociedad Anonima (YPF)	2003-2008	566.13%

Large-cap stocks are treated as having a market cap of $10B+.