NetEase (NTES) had the highest return between 2002 and 2008 by a large-cap US stock, returning 11,671.9%.

ASSET	YEARS	% RETURN
NetEase (NTES)	2002-2008	11,671.85%
Monster Beverage (MNST)	2002-2008	6,221.72%
Bancolombia SA ADR (CIB)	2002-2008	1,891.08%
Clean Harbors (CLH)	2002-2008	1,793.73%
Deckers Outdoor (DECK)	2002-2008	1,706.68%
Banco Bradesco SA ADR (BBD)	2002-2008	1,633.8%
ArcelorMittal SA ADR (MT)	2002-2008	1,566.34%
Southern Copper (SCCO)	2002-2008	1,226.94%
Sociedad Quimica y Minera de Chile SA ADR B (SQM)	2002-2008	959.58%
Royal Gold (RGLD)	2002-2008	916.2%
Vale SA ADR (VALE)	2002-2008	881.88%
Alamos Gold (AGI)	2002-2008	774.34%
Kinross Gold (KGC)	2002-2008	768.5%
Apple (AAPL)	2002-2008	674.11%
Tenaris SA ADR (TS)	2002-2008	650.84%
Old Dominion Freight Line (ODFL)	2002-2008	620.66%
Canadian Natural Resources (CNQ)	2002-2008	608.13%
Credicorp (BAP)	2002-2008	603.96%
Elbit Systems (ESLT)	2002-2008	586.43%
Petroleo Brasileiro Petrobras SA ADR (PBR)	2002-2008	561.31%
Intuitive Surgical (ISRG)	2002-2008	547.87%
BHP (BHP)	2002-2008	536.85%
Gilead Sciences (GILD)	2002-2008	529.11%
Petróleo Brasileiro SA - Petrobras (PBR.A)	2002-2008	508.03%
Telkom Indonesia (Persero) Tbk PT ADR Rep 100 B (TLK)	2002-2008	506.45%

Large-cap stocks are treated as having a market cap of $10B+.