Know Labs (KNW) had the highest return between 2004 and 2010 by a US stock, returning 4,885,152.2%.

ASSET	YEARS	% RETURN
Know Labs (KNW)	2004-2010	4,885,152.16%
Perspective Therapeutics (CATX)	2004-2010	376,566.67%
Aris Mining (ARMN)	2004-2010	326,443.75%
Gulf Resources (GURE)	2004-2010	53,350%
Pioneer Power Solutions (PPSI)	2004-2010	29,429.23%
Ainos (AIMD)	2004-2010	28,579.25%
Universal Insurance (UVE)	2004-2010	13,793.12%
Ammo (POWW)	2004-2010	11,900%
VirnetX (VHC)	2004-2010	10,623.71%
International Tower Hill Mines (THM)	2004-2010	9,536.36%
BTCS (BTCS)	2004-2010	5,920%
Monster Beverage (MNST)	2004-2010	4,856.43%
Champions Oncology (CSBR)	2004-2010	4,400%
Insteel Industries (IIIN)	2004-2010	3,410.1%
BRF SA ADR (BRFS)	2004-2010	3,027%
Apple (AAPL)	2004-2010	2,894.14%
Broadwind Energy (BWEN)	2004-2010	2,672.11%
Houston American Energy (HUSA)	2004-2010	2,585.98%
NeoGenomics (NEO)	2004-2010	2,500%
Frontline (FRO)	2004-2010	2,480.32%
Gold Resource (GORO)	2004-2010	2,476.99%
Companhia Energetica de Minas Gerais CEMIG Pref ADR (CIG)	2004-2010	2,453.13%
Oramed Pharmaceuticals (ORMP)	2004-2010	2,387.91%
Banco Bradesco SA ADR (BBD)	2004-2010	2,254.97%
Booking (BKNG)	2004-2010	2,113.57%