Netflix (NFLX) had the highest return between 2012 and 2016 by a US stock in the S&P 500 (GSPC), returning 1,133.1%.

ASSET	YEARS	% RETURN
Netflix (NFLX)	2012-2016	1,133.07%
Caesars Entertainment (CZR)	2012-2016	801.6%
NVIDIA (NVDA)	2012-2016	702.07%
Texas Pacific Land Trust (TPL)	2012-2016	658.2%
Constellation Brands Inc Class A (STZ)	2012-2016	644.05%
Tesla (TSLA)	2012-2016	638.4%
Incyte (INCY)	2012-2016	566.25%
Broadcom (AVGO)	2012-2016	550.8%
Regeneron Pharmaceuticals (REGN)	2012-2016	549.6%
DexCom (DXCM)	2012-2016	527.1%
Delta Air Lines (DAL)	2012-2016	521.68%
NXP Semiconductors (NXPI)	2012-2016	521.1%
Huntington Ingalls Industries (HII)	2012-2016	506.25%
Southwest Airlines (LUV)	2012-2016	492.35%
Monolithic Power Systems (MPWR)	2012-2016	475.62%
Diamondback Energy (FANG)	2012-2016	467.12%
Builders FirstSource (BLDR)	2012-2016	422.38%
Domino's Pizza Inc Common Stock (DPZ)	2012-2016	422.2%
MarketAxess (MKTX)	2012-2016	420.21%
Charter Communications (CHTR)	2012-2016	400.56%
Smith AO (AOS)	2012-2016	391.44%
Corpay (CPAY)	2012-2016	372.21%
Lennox International (LII)	2012-2016	369.22%
EPAM Systems (EPAM)	2012-2016	367.71%
Axon Enterprise (AXON)	2012-2016	362.6%