NVIDIA (NVDA) has had the highest return between 2021 and 2025 by a US stock with a market cap of $40B+, returning 966.5%.

ASSET	YEARS	% RETURN
NVIDIA (NVDA)	2021-2025	966.47%
Vistra Energy (VST)	2021-2025	853.11%
Constellation Energy (CEG)	2021-2025	781.21%
Targa Resources (TRGP)	2021-2025	748.13%
MicroStrategy (MSTR)	2021-2025	702.18%
Applovin (APP)	2021-2025	608.57%
Arista Networks (ANET)	2021-2025	511.14%
Vertiv (VRT)	2021-2025	487.84%
Axon Enterprise (AXON)	2021-2025	477.2%
Broadcom (AVGO)	2021-2025	473%
Eli Lilly and (LLY)	2021-2025	431.3%
Palantir Technologies Inc Class A Common Stock (PLTR)	2021-2025	421.2%
Howmet Aerospace (HWM)	2021-2025	385.36%
Energy Transfer (ET)	2021-2025	355.61%
Ares Management (ARES)	2021-2025	348.23%
Marathon Petroleum (MPC)	2021-2025	324.94%
Quanta Services (PWR)	2021-2025	308.78%
GE Aerospace (GE)	2021-2025	293.7%
Interactive Brokers (IBKR)	2021-2025	291.84%
Petroleo Brasileiro Petrobras SA ADR (PBR)	2021-2025	290.07%
Diamondback Energy (FANG)	2021-2025	284.25%
Fortinet (FTNT)	2021-2025	281.96%
MPLX (MPLX)	2021-2025	267.98%
Cheniere Energy (LNG)	2021-2025	265.63%
Apollo Global Management LLC Class A (APO)	2021-2025	265.44%