Advanced Micro Devices (AMD) had the highest return between 2016 and 2022 by a US stock with a market cap of $60B+, returning 2,238.3%.

ASSET	YEARS	% RETURN
Advanced Micro Devices (AMD)	2016-2022	2,238.27%
NVIDIA (NVDA)	2016-2022	1,753.6%
Shopify (SHOP)	2016-2022	1,265.46%
Cadence Design Systems (CDNS)	2016-2022	703.2%
Tesla (TSLA)	2016-2022	700.84%
Fortinet (FTNT)	2016-2022	700.43%
MercadoLibre (MELI)	2016-2022	658.11%
Ares Management (ARES)	2016-2022	650.95%
Synopsys (SNPS)	2016-2022	607.8%
ASML Holding NV ADR (ASML)	2016-2022	573.82%
KLA-Tencor (KLAC)	2016-2022	542.85%
Deere (DE)	2016-2022	540.81%
Arista Networks (ANET)	2016-2022	523.51%
Apollo Global Management LLC Class A (APO)	2016-2022	521%
Danaher (DHR)	2016-2022	520.96%
Petróleo Brasileiro SA - Petrobras (PBR.A)	2016-2022	510.49%
Lam Research (LRCX)	2016-2022	503.18%
Applied Materials (AMAT)	2016-2022	481.56%
Apple (AAPL)	2016-2022	453.26%
Cintas (CTAS)	2016-2022	440.58%
Arthur J Gallagher (AJG)	2016-2022	438.91%
Petroleo Brasileiro Petrobras SA ADR (PBR)	2016-2022	418.11%
Progressive (PGR)	2016-2022	411.85%
Eli Lilly and (LLY)	2016-2022	408.46%
UnitedHealth (UNH)	2016-2022	403.91%