MicroStrategy (MSTR) has had the highest return between 2020 and 2024 by a large-cap US stock, returning 2,645.7%.

ASSET	YEARS	% RETURN
MicroStrategy (MSTR)	2020-2024	2,645.66%
NVIDIA (NVDA)	2020-2024	2,210.64%
GameStop (GME)	2020-2024	1,772.96%
Super Micro Computer (SMCI)	2020-2024	1,490.36%
Tesla (TSLA)	2020-2024	1,377.39%
Antero Resources (AR)	2020-2024	1,047.57%
Vertiv (VRT)	2020-2024	1,028.34%
Summit Therapeutics (SMMT)	2020-2024	1,016.88%
Celestica (CLS)	2020-2024	995.19%
Fortress Transp & Infra Inv (FTAI)	2020-2024	952.66%
Comfort Systems USA (FIX)	2020-2024	863.4%
Axon Enterprise (AXON)	2020-2024	759.78%
Arista Networks (ANET)	2020-2024	731.43%
Quanta Services (PWR)	2020-2024	728.34%
Futu (FUTU)	2020-2024	714.14%
Sprouts Farmers Market LLC (SFM)	2020-2024	671.07%
Palantir Technologies Inc Class A Common Stock (PLTR)	2020-2024	632%
Crowdstrike (CRWD)	2020-2024	630.56%
Deckers Outdoor (DECK)	2020-2024	620.01%
Vistra Energy (VST)	2020-2024	615.17%
Builders FirstSource (BLDR)	2020-2024	566.98%
Cloudflare (NET)	2020-2024	566.42%
Flex (FLEX)	2020-2024	557.24%
Carrier Global (CARR)	2020-2024	551.08%
Broadcom (AVGO)	2020-2024	549.94%

Large-cap stocks are treated as having a market cap of $10B+.