Advanced Micro Devices (AMD) had the highest return between 2016 and 2019 by a large-cap US stock, returning 1,555.6%.

ASSET	YEARS	% RETURN
Advanced Micro Devices (AMD)	2016-2019	1,555.6%
Shopify (SHOP)	2016-2019	1,464.04%
EXACT Sciences (EXAS)	2016-2019	929.84%
Trade Desk (TTD)	2016-2019	803.58%
argenx NV ADR (ARGX)	2016-2019	796.76%
Roku (ROKU)	2016-2019	748.54%
Enphase Energy (ENPH)	2016-2019	661.81%
NVIDIA (NVDA)	2016-2019	643.58%
Centrais Electricas Brasileiras (EBR)	2016-2019	630.74%
Paycom Soft (PAYC)	2016-2019	613.45%
Carvana (CVNA)	2016-2019	581.85%
Texas Pacific Land Trust (TPL)	2016-2019	534.18%
Ubiquiti Networks (UI)	2016-2019	499.92%
Kinsale Capital (KNSL)	2016-2019	475.99%
BeiGene (BGNE)	2016-2019	472.18%
Wix (WIX)	2016-2019	450.52%
Burlington Stores (BURL)	2016-2019	445%
Huazhu (HTHT)	2016-2019	434.72%
MercadoLibre (MELI)	2016-2019	412.37%
Veeva Systems Inc Class A (VEEV)	2016-2019	395.81%
Teck Resources Ltd Class B (TECK)	2016-2019	395.75%
Block (SQ)	2016-2019	390.67%
Okta (OKTA)	2016-2019	389.69%
Copart (CPRT)	2016-2019	383.62%
Petróleo Brasileiro SA - Petrobras (PBR.A)	2016-2019	372.35%

Large-cap stocks are treated as having a market cap of $10B+.