Sarepta Therapeutics (SRPT) had the highest return between 2012 and 2012 by a large-cap US stock, returning 469.5%.

ASSET	YEARS	% RETURN
Sarepta Therapeutics (SRPT)	2012-2012	469.54%
Regeneron Pharmaceuticals (REGN)	2012-2012	202.73%
PulteGroup (PHM)	2012-2012	180.68%
Builders FirstSource (BLDR)	2012-2012	165.71%
American Airlines (AAL)	2012-2012	159.62%
Alnylam Pharmaceuticals (ALNY)	2012-2012	119.09%
Insmed (INSM)	2012-2012	114.42%
Genmab A-S (GMAB)	2012-2012	114.07%
Cheniere Energy (LNG)	2012-2012	111.25%
Expedia (EXPE)	2012-2012	110.28%
Westlake Chemical (WLK)	2012-2012	104.76%
Bank of America (BAC)	2012-2012	102.89%
Nomura Holdings Inc ADR (NMR)	2012-2012	100.41%
Lloyds Banking Group PLC ADR (LYG)	2012-2012	97.52%
Lennar (LEN)	2012-2012	93.77%
Booz Allen Hamilton (BAH)	2012-2012	93.12%
Lennar (LEN.B)	2012-2012	91.21%
Seagate Technology (STX)	2012-2012	90.71%
LyondellBasell Industries (LYB)	2012-2012	89.63%
Marathon Petroleum (MPC)	2012-2012	87.16%
Smurfit WestRock (SW)	2012-2012	83.21%
Illumina (ILMN)	2012-2012	79.32%
Corpay (CPAY)	2012-2012	79.01%
Saia (SAIA)	2012-2012	78.81%
Guidewire Software (GWRE)	2012-2012	77.43%

Large-cap stocks are treated as having a market cap of $10B+.