Exelixis (EXEL) had the highest return between 2015 and 2017 by a large-cap US stock, returning 1,968%.

ASSET	YEARS	% RETURN
Exelixis (EXEL)	2015-2017	1,968.03%
NVIDIA (NVDA)	2015-2017	890.38%
Huazhu (HTHT)	2015-2017	459.74%
Netflix (NFLX)	2015-2017	290.55%
Take-Two Interactive Software (TTWO)	2015-2017	289.29%
Align Technology (ALGN)	2015-2017	288.17%
Arista Networks (ANET)	2015-2017	287.72%
Texas Pacific Land Trust (TPL)	2015-2017	285.78%
Sarepta Therapeutics (SRPT)	2015-2017	281.62%
Advanced Micro Devices (AMD)	2015-2017	280.74%
Amazon (AMZN)	2015-2017	274.13%
Shopify (SHOP)	2015-2017	260.71%
NetEase (NTES)	2015-2017	260.25%
argenx NV ADR (ARGX)	2015-2017	252.74%
Neurocrine Biosciences (NBIX)	2015-2017	243.47%
Coherent (COHR)	2015-2017	241.21%
BeiGene (BGNE)	2015-2017	237.31%
Topbuild (BLD)	2015-2017	232.92%
STMicroelectronics NV ADR (STM)	2015-2017	220.85%
Builders FirstSource (BLDR)	2015-2017	213.98%
Block (SQ)	2015-2017	209.55%
Paycom Soft (PAYC)	2015-2017	205.55%
BWX Technologies (BWXT)	2015-2017	187.1%
NVR (NVR)	2015-2017	181.34%
Sociedad Quimica y Minera de Chile SA ADR B (SQM)	2015-2017	177.99%

Large-cap stocks are treated as having a market cap of $10B+.