Jose Lima has the highest career ERA, with an ERA of 5.26.

Interpreted as:

worst era with a minimum of 1500 IP by a player in MLB history

	NAME	ERA	IP	G	W	L	W%	GS	SO	CG	SHO	SV	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Jose Lima J. Lima	5.26	1567.2	348	89	102	.466	235	980	9	1	5	1,783	917	972	267	393	53	40	27	6,790	43	5.63	2.26	2.49	1.53	14.4	5.8	1.39	.297	5.58	119	4.90	111	10.24	-88.6
2	Jordan Lyles J. Lyles	5.22	1509.0	357	72	107	.402	245	1,145	5	1	2	1,626	876	950	237	493	67	36	16	6,586	60	6.83	2.94	2.32	1.41	17.4	7.5	1.40	.299	5.67	124	4.77	115	9.70	-101.4
3	Sidney Ponson S. Ponson	5.03	1760.1	298	91	113	.446	278	1,031	29	4	1	2,004	983	1,051	223	609	45	7	19	7,676	53	5.27	3.11	1.69	1.14	13.4	7.9	1.48	.309	5.37	112	4.66	103	10.25	-21.7
4	Eric Milton E. Milton	4.99	1582.1	271	89	85	.511	270	1,127	10	4	0	1,665	878	935	267	453	35	0	14	6,826	29	6.41	2.58	2.49	1.52	16.5	6.6	1.34	.283	5.32	108	4.77	106	9.47	-42.6
5	Jack Knott J. Knott	4.97	1557.0	325	82	103	.443	192	484	62	4	19	1,787	860	991	140	642	20	78		7,007	42	2.80	3.71	0.75	0.81	6.9	9.2	1.56	.288	5.73	107	4.76	106	10.33	-37.9
6	Kid Carsey K. Carsey	4.95	2233.1	296	116	138	.457	257	486	218	4	3	2,794	1,229	1,728	80	800	125	38		10,251	92	1.96	3.22	0.61	0.32	4.7	7.8	1.61	.310	6.96	118	4.36	103	11.26	-39.1
7	Bobby Witt B. Witt	4.83	2465.0	430	142	157	.475	397	1,955	47	11	0	2,493	1,324	1,449	252	1,375	39	13	37	11,003	128	7.14	5.02	1.42	0.92	17.8	12.5	1.57	.304	5.29	111	4.41	102	9.10	-26.2
8	Jamey Wright J. Wright	4.81	2036.2	719	97	130	.427	248	1,189	6	3	2	2,168	1,088	1,208	200	978	155	133	73	9,038	87	5.25	4.32	1.22	0.88	13.2	10.8	1.54	.302	5.34	105	4.86	109	9.58	-84.5
9	Brian Moehler B. Moehler	4.81	1567.1	332	84	107	.440	252	859	11	6	1	1,834	837	897	199	454	36	40	37	6,844	25	4.93	2.61	1.89	1.14	12.6	6.6	1.46	.309	5.15	108	4.60	102	10.53	-11.7
10	Herm Wehmeier H. Wehmeier	4.80	1803.0	361	92	108	.460	240	794	79	9	9	1,806	961	1,044	210	852	31	48	22	7,925	48	3.96	4.25	0.93	1.05	10.0	10.8	1.47	.264	5.21	120	4.58	113	9.01	-107
11	Edwin Jackson E. Jackson	4.78	1960.0	412	107	133	.446	318	1,508	5	3	1	2,094	1,040	1,135	249	779	39	30	39	8,569	108	6.92	3.58	1.94	1.14	17.6	9.1	1.47	.308	5.21	116	4.47	108	9.62	-74.1
12	Brian Anderson B. Anderson	4.74	1547.0	291	82	83	.497	245	723	12	4	1	1,743	814	906	264	337	23	11	28	6,532	22	4.21	1.96	2.15	1.54	11.1	5.2	1.34	.285	5.27	103	5.06	111	10.14	-85.6
13	Jaime Navarro J. Navarro	4.72	2055.1	361	116	126	.479	309	1,113	32	8	2	2,313	1,078	1,206	214	690	67	16	44	9,021	92	4.87	3.02	1.61	0.94	12.3	7.6	1.46	.303	5.28	109	4.37	102	10.13	-25.4
14	Shawn Estes S. Estes	4.71	1678.1	283	101	93	.521	281	1,210	14	8	0	1,708	879	950	158	858	57	0	36	7,403	79	6.49	4.60	1.41	0.85	16.3	11.6	1.53	.303	5.09	110	4.49	103	9.16	-23.6
15	Jeff Weaver J. Weaver	4.71	1838.0	355	104	119	.466	274	1,214	16	7	2	1,997	961	1,023	227	516	124	21	44	7,970	37	5.94	2.53	2.35	1.11	15.2	6.5	1.37	.301	5.01	107	4.40	100	9.78	3
16	Jeff Suppan J. Suppan	4.70	2542.2	448	140	146	.490	417	1,390	16	5	0	2,843	1,328	1,451	337	871	94	16	58	11,139	89	4.92	3.08	1.60	1.19	12.5	7.8	1.46	.297	5.14	105	4.85	109	10.06	-111.6
17	Rick Helling R. Helling	4.68	1526.1	301	93	81	.534	234	1,058	10	4	0	1,540	793	842	247	562	48	22	24	6,564	48	6.24	3.31	1.88	1.46	16.1	8.6	1.38	.278	4.96	100	5.00	108	9.08	-61.1
18	Vern Kennedy V. Kennedy	4.67	2025.2	344	104	132	.441	263	691	127	7	6	2,173	1,052	1,202	130	1,049	24	56		9,055	54	3.07	4.66	0.66	0.58	7.6	11.6	1.59	.285	5.34	107	4.60	108	9.65	-72.9
19	Pedro Astacio P. Astacio	4.67	2196.2	392	129	124	.510	343	1,664	31	12	0	2,292	1,140	1,213	291	726	111	11	54	9,472	59	6.82	2.97	2.29	1.19	17.6	7.7	1.37	.300	4.97	104	4.42	100	9.39	0.2
20	Omar Olivares O. Olivares	4.67	1591.2	349	77	86	.472	229	853	16	2	4	1,678	826	889	159	685	80	42	30	6,966	46	4.82	3.87	1.25	0.90	12.2	9.8	1.48	.293	5.03	107	4.70	108	9.49	-58.4
21	Brett Tomko B. Tomko	4.65	1816.0	397	100	103	.493	266	1,209	13	2	2	1,898	939	1,011	255	582	37	39	52	7,824	63	5.99	2.88	2.08	1.26	15.5	7.4	1.37	.286	5.01	109	4.59	106	9.41	-56
22	Esteban Loaiza E. Loaiza	4.65	2099.0	377	126	114	.525	333	1,382	14	6	1	2,352	1,084	1,170	259	604	75	16	40	9,106	32	5.93	2.59	2.29	1.11	15.2	6.6	1.41	.308	5.02	103	4.33	97	10.08	36.8
23	Bill Hart B. Hart	4.65	1582.0	206	66	120	.355	190	431	162	5	3	1,819	817	1,214	43	704	71	16		7,243	80	2.45	4.01	0.61	0.24	6.0	9.7	1.59	.297	6.91	115	4.43	110	10.35	-71.1
24	Jason Hammel J. Hammel	4.62	1810.1	377	96	114	.457	298	1,428	2	1	4	1,919	929	987	232	567	71	41	30	7,826	77	7.10	2.82	2.52	1.15	18.2	7.2	1.37	.305	4.91	108	4.25	102	9.54	-19.4
25	Bruce Chen B. Chen	4.62	1532.0	400	82	81	.503	227	1,140	4	1	1	1,578	786	849	257	546	45	56	40	6,619	30	6.70	3.21	2.09	1.51	17.2	8.2	1.39	.285	4.99	108	4.91	115	9.27	-108.7