The Philadelphia Athletics had their most runs in a game on May 1, 1929 and on May 18, 1912, with 24 runs.

Interpreted as:

most runs in a regular-season game by athletics

	TEAM	R	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Athletics	24	5/1/1929	PHA	@	BSA	W 24-6	52	29	6	0	3	23	6	1	4	1	2	60	44	9	1				.558	.610	.846	1.456
2	Athletics	24	5/18/1912	PHA	vs	DET	W 24-2	43	26	4	6	0	22	7	0	1	10		52	42	10	2				.605	.660	.977	1.637
3	Athletics	23	9/30/2000	OAK	vs	TEX	W 23-2	48	24	5	0	4	23	10	0	10	0	0	58	41	9	0	0	0	0	.500	.586	.854	1.440
4	Athletics	22	7/8/1902	PHA	@	BSA	W 22-9	50	27	3	1	2	22	3	0	2	0	-13	56	38	6	3		-13	-13	.540	.566	.760	1.326
5	Athletics	21	9/10/2019	OAK	@	HOU	W 21-7	51	25	3	0	6	21	4	0	7	0	0	56	46	9	0	1	0	0	.490	.518	.902	1.420
6	Athletics	21	9/20/2018	OAK	vs	LAA	W 21-3	44	22	4	0	3	20	7	0	7	0	0	51	35	7	0	0	0	2	.500	.569	.795	1.364
7	Athletics	21	6/18/2000	OAK	@	KCR	W 21-3	46	21	5	0	4	21	10	0	8	0	0	57	38	9	0	1	0	0	.457	.544	.826	1.370
8	Athletics	21	6/14/1969	OAK	@	BOS	W 21-7	51	25	4	0	3	19	9	1	6	2	0	62	38	7	0	1	0	2	.490	.565	.745	1.310
9	Athletics	21	7/25/1929	PHA	vs	CLE	W 21-3	46	25	6	0	4	20	4	0	0	4	0	52	43	10	2				.543	.580	.935	1.515
10	Athletics	21	8/9/1923	PHA	vs	CWS	W 21-5	44	22	3	1	2	19	7	0	4	1	0	51	33	6	0				.500	.569	.750	1.319
11	Athletics	21	9/23/1913	PHA	vs	DET	W 21-8	46	25	2	2	0	19	5	2	2	2		54	31	4	1				.543	.604	.674	1.278
12	Athletics	20	5/4/2024	OAK	vs	MIA	W 20-4	45	21	1	1	6	20	6	3	3	0	0	54	42	8	0	0	0	1	.467	.556	.933	1.489
13	Athletics	20	8/31/2012	OAK	vs	BOS	W 20-2	44	19	5	0	5	20	2	1	4	0	0	47	39	10	0	0	0	0	.432	.468	.886	1.354
14	Athletics	20	4/25/1961	KCA	vs	MIN	W 20-2	39	16	5	3	0	17	10	0	5	0	0	50	27	8	0	1	1	0	.410	.520	.692	1.212
15	Athletics	20	5/21/1925	PHA	@	SLA	W 20-4	45	19	2	2	5	20	6	1	3	0	0	53	40	9	1				.422	.500	.889	1.389
16	Athletics	19	7/6/2024	OAK	vs	BAL	W 19-8	41	18	5	0	5	19	6	1	6	0	0	49	38	10	0	1	0	0	.439	.510	.927	1.437
17	Athletics	19	8/26/2019	OAK	@	KCR	W 19-4	49	22	2	1	4	19	6	0	8	0	0	55	38	7	0	0	0	0	.449	.509	.776	1.285
18	Athletics	19	9/29/1991	OAK	vs	TEX	W 19-5	40	18	4	0	1	19	6	2	3	0	0	49	25	5	0	1	0	0	.450	.531	.625	1.156
19	Athletics	19	8/29/1989	OAK	@	NYY	W 19-5	46	18	2	2	2	17	5	1	6	1	0	52	30	6	0	0	0	0	.391	.462	.652	1.114
20	Athletics	19	5/15/1985	OAK	@	MIL	W 19-3	46	19	4	0	3	16	8	0	7	0	0	55	32	7	0	1	0	0	.413	.491	.696	1.187
21	Athletics	19	9/13/1935	PHA	vs	CWS	W 19-7	40	19	2	0	2	19	9	1	3	0	1	51	27	4	1				.475	.580	.675	1.255
22	Athletics	19	5/1/1930	PHA	vs	DET	W 19-2	40	18	3	2	5	19	4	1	4	0	0	47	40	10	2				.450	.511	1.000	1.511
23	Athletics	19	9/5/1912	PHA	@	NYH	W 19-9	47	23	4	4	0	18	4	0	6	2		53	35	8	2				.489	.529	.745	1.274
24	Athletics	19	5/7/1903	PHA	vs	WSH	W 19-5	48	22	4	1	2	15	4	0	3	3	-10	53	34	7	1		-10	-10	.458	.500	.708	1.208
25	Athletics	18	7/14/2024	OAK	@	PHI	W 18-3	40	15	2	1	8	18	5	0	5	0	1	46	43	11	0	1	0	0	.375	.435	1.075	1.510