Warren Spahn has won the most career games by a left-hander, with 363 wins.

Interpreted as:

most career regular-season wins by a lefty pitcher

	NAME	W	L	W%	G	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Warren Spahn W. Spahn	363	245	.597	750	665	3.09	2,583	382	63	28	5243.2	4,830	1,798	2,016	434	1,434	42	67	60	21,547	81	4.43	2.46	1.80	0.74	12.0	6.7	1.19	.258	3.46	84	3.44	94	8.29	124.4
2	Steve Carlton S. Carlton	329	244	.574	741	709	3.22	4,136	254	55	2	5217.2	4,672	1,864	2,130	414	1,833	53	13	150	21,683	183	7.13	3.16	2.26	0.71	19.1	8.5	1.25	.279	3.67	87	3.14	86	8.06	271.5
3	Eddie Plank E. Plank	326	194	.627	623	529	2.35	2,246	410	69	23	4495.2	3,958	1,174	1,566	42	1,072	190	77		17,803	88	4.50	2.15	2.10	0.08	12.6	6.0	1.12	.275	3.14	81	2.45	86	7.92	195.2
4	Tom Glavine T. Glavine	305	203	.600	682	682	3.54	2,607	56	25	0	4413.1	4,298	1,734	1,900	356	1,500	66	0	145	18,604	65	5.32	3.06	1.74	0.73	14.0	8.1	1.31	.280	3.87	86	3.94	94	8.76	120.1
5	Randy Johnson R. Johnson	303	166	.646	618	603	3.29	4,875	100	37	2	4135.1	3,346	1,513	1,703	411	1,497	190	7	37	17,067	109	10.61	3.26	3.26	0.89	28.6	8.8	1.17	.291	3.71	75	3.18	73	7.28	554.3
6	Lefty Grove L. Grove	300	141	.680	616	457	3.06	2,266	298	35	54	3940.2	3,849	1,339	1,594	162	1,187	42	123		16,622	51	5.18	2.71	1.91	0.37	13.6	7.1	1.28	.284	3.64	68	3.36	76	8.79	462.8
7	Tommy John T. John	288	231	.555	760	700	3.34	2,245	162	46	3	4710.1	4,783	1,749	2,017	302	1,259	98	22	102	19,692	187	4.29	2.41	1.78	0.58	11.4	6.4	1.28	.284	3.85	90	3.37	89	9.14	208.3
8	Jim Kaat J. Kaat	283	237	.544	898	625	3.45	2,461	180	31	17	4530.1	4,620	1,738	2,038	395	1,083	122	102	116	19,023	128	4.89	2.15	2.27	0.78	12.9	5.7	1.26	.282	4.05	93	3.41	91	9.18	165.8
9	Jamie Moyer J. Moyer	269	209	.563	696	638	4.25	2,441	33	10	0	4074.0	4,231	1,926	2,076	522	1,155	146	15	69	17,356	57	5.39	2.55	2.11	1.15	14.1	6.7	1.32	.283	4.59	97	4.46	102	9.35	-33.5
10	Eppa Rixey E. Rixey	266	251	.515	692	554	3.15	1,350	290	37	14	4494.2	4,633	1,572	1,986	93	1,082	76	99		18,754	97	2.70	2.17	1.25	0.19	7.2	5.8	1.27	.281	3.98	88	3.29	91	9.28	162.7
11	Andy Pettitte A. Pettitte	256	153	.626	531	521	3.85	2,448	26	4	0	3316.0	3,448	1,418	1,572	288	1,031	55	3	42	14,074	69	6.64	2.80	2.37	0.78	17.4	7.3	1.35	.308	4.27	86	3.73	83	9.36	282.1
12	Carl Hubbell C. Hubbell	253	154	.622	535	433	2.98	1,677	260	36	33	3590.1	3,461	1,188	1,380	227	725	53	82		14,805	53	4.20	1.82	2.31	0.57	11.3	4.9	1.17	.267	3.46	76	3.55	89	8.68	174.2
13	CC Sabathia	251	161	.609	561	560	3.74	3,093	38	12	0	3577.1	3,404	1,485	1,623	382	1,099	123	0	44	14,989	74	7.78	2.76	2.81	0.96	20.6	7.3	1.26	.294	4.08	87	3.77	87	8.56	223.7
14	Herb Pennock H. Pennock	241	162	.598	617	419	3.60	1,227	249	35	37	3571.2	3,900	1,428	1,699	128	916	36	135		15,096	65	3.09	2.31	1.34	0.32	8.1	6.1	1.35	.295	4.28	95	3.50	93	9.83	113.6
15	Frank Tanana F. Tanana	240	236	.504	638	616	3.66	2,773	143	34	1	4188.1	4,063	1,704	1,910	448	1,255	129	10	116	17,641	119	5.96	2.70	2.21	0.96	15.7	7.1	1.27	.277	4.10	94	3.78	96	8.73	66.4
16	David Wells D. Wells	239	157	.604	660	489	4.13	2,201	54	12	13	3439.0	3,635	1,578	1,702	407	719	83	65	65	14,413	101	5.76	1.88	3.06	1.07	15.3	5.0	1.27	.293	4.45	93	3.99	90	9.51	172.9
17	Whitey Ford W. Ford	236	106	.690	498	438	2.75	1,956	156	45	11	3170.1	2,766	967	1,107	228	1,086	28	35	44	13,036	75	5.55	3.08	1.80	0.65	15.0	8.3	1.22	.261	3.14	75	3.26	88	7.85	156.9
18	Jerry Koosman J. Koosman	222	209	.515	612	527	3.36	2,556	140	33	17	3839.1	3,635	1,433	1,608	290	1,198	71	43	121	15,996	89	5.99	2.81	2.13	0.68	16.0	7.5	1.26	.282	3.77	92	3.25	90	8.52	152.5
19	Jerry Reuss J. Reuss	220	191	.535	628	547	3.64	1,907	127	39	11	3669.2	3,734	1,483	1,700	245	1,127	59	41	118	15,582	107	4.68	2.76	1.69	0.60	12.2	7.2	1.32	.285	4.17	100	3.45	95	9.16	68.4
20	Kenny Rogers K. Rogers	219	156	.584	762	474	4.27	1,968	36	9	28	3302.2	3,457	1,568	1,739	339	1,175	127	133	53	14,280	79	5.36	3.20	1.67	0.92	13.8	8.2	1.40	.292	4.74	93	4.38	97	9.42	43.3
21	Earl Whitehill E. Whitehill	218	185	.541	541	473	4.36	1,350	226	16	11	3564.2	3,917	1,726	2,018	192	1,431	101	46		15,781	43	3.41	3.61	0.94	0.48	8.6	9.1	1.50	.293	5.10	99	4.29	99	9.89	6
22	Mickey Lolich M. Lolich	217	191	.532	586	496	3.44	2,832	195	41	10	3638.1	3,366	1,390	1,537	347	1,099	92	40	67	15,140	124	7.01	2.72	2.58	0.86	18.7	7.3	1.23	.280	3.80	96	3.19	87	8.33	188.5
23	Wilbur Cooper W. Cooper	216	178	.548	517	406	2.89	1,252	279	35	14	3480.0	3,415	1,119	1,406	103	853	100	83		14,377	44	3.24	2.21	1.47	0.27	8.7	5.9	1.23	.274	3.64	86	3.17	94	8.83	72.2
24	Mark Buehrle M. Buehrle	214	160	.572	518	493	3.81	1,870	33	10	0	3283.1	3,472	1,391	1,542	361	734	79	6	49	13,705	27	5.13	2.01	2.55	0.99	13.6	5.4	1.28	.292	4.23	87	4.11	93	9.52	111.9
25	Clayton Kershaw C. Kershaw	212	94	.693	432	429	2.50	2,968	25	15	0	2742.2	2,091	762	835	227	678	44	1	28	10,816	103	9.74	2.22	4.38	0.74	27.4	6.3	1.01	.270	2.74	64	2.82	70	6.86	366.8