Rickey Henderson has smashed the most career homers when leading off a game, with 81 homers.

Interpreted as:

most career MLB leadoff home runs by a player

	NAME	HR	G	AB	H	2B	3B	RBI	BB	HBP	SO	PA	TB	XBH	SH	SF	IBB	AVG	OBP	SLG	OPS
1	Rickey Henderson R. Henderson	81	2,875	2,462	680	117	17	81	394	19	408	2,875	1,074	215	0	0	0	.276	.380	.436	.816
2	George Springer G. Springer	60	1,009	908	259	37	4	60	86	12	209	1,009	484	101	0	0	0	.285	.355	.533	.888
3	Alfonso Soriano A. Soriano	54	768	723	224	58	2	54	33	12	141	768	448	114	0	0	0	.310	.350	.620	.970
4	Craig Biggio C. Biggio	53	1,560	1,407	400	106	9	53	114	39	233	1,560	683	168	0	0	0	.284	.354	.485	.840
5	Mookie Betts M. Betts	52	1,069	976	281	68	9	52	86	7	178	1,069	523	129	0	0	1	.288	.350	.536	.886
6	Ian Kinsler I. Kinsler	48	1,129	1,034	240	50	7	48	79	16	158	1,129	448	105	0	0	0	.232	.297	.433	.730
7	Curtis Granderson C. Granderson	47	986	890	223	39	12	47	89	7	220	986	427	98	0	0	0	.251	.324	.480	.803
8	Kyle Schwarber K. Schwarber	46	512	445	111	17	1	46	65	2	133	512	268	64	0	0	0	.249	.348	.602	.950
9	Jimmy Rollins J. Rollins	46	1,507	1,438	386	91	10	46	65	4	179	1,507	635	147	0	0	0	.268	.302	.442	.744
10	Brady Anderson B. Anderson	44	1,294	1,139	298	63	10	44	132	23	196	1,294	513	117	0	0	0	.262	.350	.450	.800
11	Charlie Blackmon C. Blackmon	42	1,011	945	274	54	10	42	55	11	215	1,011	474	106	0	0	0	.290	.336	.502	.838
12	Jose Altuve J. Altuve	41	907	836	266	53	3	41	62	9	123	907	448	97	0	0	0	.318	.372	.536	.907
13	Ichiro Suzuki I. Suzuki	37	1,822	1,750	544	80	16	37	65	7	182	1,822	767	133	0	0	0	.311	.338	.438	.776
14	Shin-Soo Choo S. Choo	36	730	634	203	43	4	36	75	21	134	730	362	83	0	0	0	.320	.410	.571	.981
15	Ronald Acuña Jr. R. Acuña Jr.	34	633	568	168	29	3	34	54	11	132	633	305	66	0	0	0	.296	.368	.537	.905
16	Ray Durham R. Durham	34	975	888	269	55	14	34	81	6	147	975	454	103	0	0	0	.303	.365	.511	.876
17	Devon White D. White	34	960	899	251	51	11	34	46	15	173	960	426	96	0	0	0	.279	.325	.474	.799
18	Paul Molitor P. Molitor	33	1,570	1,451	423	78	19	33	111	8	188	1,570	638	130	0	0	0	.292	.345	.440	.785
19	Marcus Semien M. Semien	31	844	767	171	37	2	31	72	5	158	844	305	70	0	0	0	.223	.294	.398	.691
20	Chuck Knoblauch C. Knoblauch	31	1,289	1,127	309	51	9	31	139	23	152	1,289	471	91	0	0	0	.274	.365	.418	.783
21	Rafael Furcal R. Furcal	30	1,389	1,301	363	54	13	30	85	2	181	1,389	533	97	0	0	0	.279	.324	.410	.734
22	Tony Phillips T. Phillips	30	1,381	1,187	317	56	7	30	190	4	249	1,381	477	93	0	0	0	.267	.370	.402	.772
23	Derek Jeter D. Jeter	29	981	908	321	50	5	29	60	13	126	981	468	84	0	0	0	.354	.402	.515	.917
24	Kenny Lofton K. Lofton	29	1,705	1,487	448	68	22	29	211	7	227	1,705	647	119	0	0	0	.301	.391	.435	.826
25	Brian Dozier B. Dozier	28	538	509	138	35	3	28	24	5	96	538	263	66	0	0	0	.271	.310	.517	.827