Rickey Henderson has gotten the most career hits when leading off a game, with 680 hits.

Interpreted as:

most career hits by a player batting leadoff

	NAME	H	G	AB	2B	3B	HR	RBI	BB	HBP	SO	PA	TB	XBH	SH	SF	IBB	AVG	OBP	SLG	OPS
1	Rickey Henderson R. Henderson	680	2,875	2,462	117	17	81	81	394	19	408	2,875	1,074	215	0	0	0	.276	.380	.436	.816
2	Ichiro Suzuki I. Suzuki	544	1,822	1,750	80	16	37	37	65	7	182	1,822	767	133	0	0	0	.311	.338	.438	.776
3	Brett Butler B. Butler	473	1,844	1,637	55	22	8	8	202	5	174	1,844	596	85	0	0	0	.289	.369	.364	.733
4	Kenny Lofton K. Lofton	448	1,705	1,487	68	22	29	29	211	7	227	1,705	647	119	0	0	0	.301	.391	.435	.826
5	Paul Molitor P. Molitor	423	1,570	1,451	78	19	33	33	111	8	188	1,570	638	130	0	0	0	.292	.345	.440	.785
6	Juan Pierre J. Pierre	420	1,439	1,349	46	15	4	4	74	16	88	1,439	508	65	0	0	0	.311	.354	.377	.731
7	Craig Biggio C. Biggio	400	1,560	1,407	106	9	53	53	114	39	233	1,560	683	168	0	0	0	.284	.354	.485	.840
8	Jose Reyes J. Reyes	393	1,445	1,359	75	16	26	26	86	0	181	1,445	578	117	0	0	0	.289	.331	.425	.757
9	Johnny Damon J. Damon	388	1,575	1,422	62	13	27	27	147	6	201	1,575	557	102	0	0	0	.273	.343	.392	.735
10	Jimmy Rollins J. Rollins	386	1,507	1,438	91	10	46	46	65	4	179	1,507	635	147	0	0	0	.268	.302	.442	.744
11	Rafael Furcal R. Furcal	363	1,389	1,301	54	13	30	30	85	2	181	1,389	533	97	0	0	0	.279	.324	.410	.734
12	Tim Raines T. Raines	361	1,398	1,252	60	26	16	16	137	9	146	1,398	521	102	0	0	0	.288	.363	.416	.779
13	Willie Wilson W. Wilson	352	1,376	1,298	31	21	11	11	67	11	208	1,376	458	63	0	0	0	.271	.313	.353	.665
14	Derek Jeter D. Jeter	321	981	908	50	5	29	29	60	13	126	981	468	84	0	0	0	.354	.402	.515	.917
15	Tony Phillips T. Phillips	317	1,381	1,187	56	7	30	30	190	4	249	1,381	477	93	0	0	0	.267	.370	.402	.772
16	Shannon Stewart S. Stewart	309	1,169	1,075	61	7	23	23	81	13	134	1,169	453	91	0	0	0	.287	.345	.421	.766
17	Chuck Knoblauch C. Knoblauch	309	1,289	1,127	51	9	31	31	139	23	152	1,289	471	91	0	0	0	.274	.365	.418	.783
18	Vince Coleman V. Coleman	303	1,275	1,149	42	20	5	5	118	8	232	1,275	400	67	0	0	0	.264	.336	.348	.685
19	Brady Anderson B. Anderson	298	1,294	1,139	63	10	44	44	132	23	196	1,294	513	117	0	0	0	.262	.350	.450	.800
20	Eric Young E. Young	296	1,242	1,097	59	14	20	20	128	17	112	1,242	443	93	0	0	0	.270	.355	.404	.759
21	Pete Rose P. Rose	285	1,097	1,001	56	3	5	5	87	9	60	1,097	362	64	0	0	0	.285	.347	.362	.709
22	Mookie Betts M. Betts	281	1,069	976	68	9	52	52	86	7	178	1,069	523	129	0	0	1	.288	.350	.536	.886
23	Al Bumbry A. Bumbry	279	1,069	970	43	11	12	12	98	1	164	1,069	380	66	0	0	0	.288	.354	.392	.745
24	Brian Roberts B. Roberts	277	1,133	1,037	74	3	13	13	96	0	138	1,133	396	90	0	0	0	.267	.329	.382	.711
25	Charlie Blackmon C. Blackmon	274	1,011	945	54	10	42	42	55	11	215	1,011	474	106	0	0	0	.290	.336	.502	.838