Since May 21, 2024, the New York Mets and the San Diego Padres are tied for the most wins, with 66 wins.

Interpreted as:

MLB team most regular-season wins since may 21

	TEAM	W	L	W%	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Mets	66	44	.600	110	3,722	551	939	202	14	158	530	357	64	970	68	16	4,171	1,643	374	1	27	7	73	.252	.326	.441	.768
2	Padres	66	41	.617	107	3,665	514	984	178	11	135	491	286	44	669	76	17	4,039	1,589	324	21	23	13	86	.268	.327	.434	.761
3	Astros	65	45	.591	110	3,772	507	984	177	12	130	482	284	46	825	59	19	4,145	1,575	319	10	33	24	91	.261	.318	.418	.735
4	Diamondbacks	65	45	.591	110	3,770	636	1,019	177	29	162	607	388	58	867	94	20	4,287	1,740	368	28	43	14	72	.270	.344	.462	.806
5	Brewers	63	47	.573	110	3,693	520	908	165	24	115	498	409	24	980	139	32	4,161	1,466	304	9	26	17	68	.246	.323	.397	.720
6	Dodgers	60	47	.561	107	3,647	546	928	190	19	159	530	377	44	883	96	15	4,106	1,633	368	8	30	22	62	.254	.329	.448	.777
7	Guardians	60	50	.545	110	3,622	467	866	166	9	131	447	318	50	813	99	27	4,029	1,443	306	13	26	15	75	.239	.307	.398	.706
8	Tigers	60	50	.545	110	3,693	466	863	162	30	120	452	312	30	999	54	21	4,064	1,445	312	4	25	6	60	.234	.297	.391	.688
9	Braves	59	54	.522	113	3,819	484	916	180	10	162	464	327	36	1,030	42	13	4,221	1,602	352	9	30	8	85	.240	.304	.419	.723
10	Phillies	59	51	.536	110	3,779	509	972	209	13	139	488	318	44	933	90	17	4,171	1,624	361	9	21	13	74	.257	.321	.430	.750
11	Cardinals	59	51	.536	110	3,755	461	943	170	14	120	440	295	35	867	66	20	4,121	1,501	304	8	28	5	65	.251	.310	.400	.709
12	Yankees	59	49	.546	108	3,651	549	894	164	12	162	528	454	31	906	56	16	4,189	1,568	338	11	42	21	84	.245	.330	.429	.760
13	Orioles	58	54	.518	112	3,831	530	954	179	22	159	512	358	45	948	62	18	4,266	1,654	360	3	29	8	53	.249	.318	.432	.750
14	Reds	57	54	.514	111	3,667	499	875	185	20	131	477	334	65	1,000	126	28	4,110	1,493	336	15	29	6	60	.239	.311	.407	.718
15	Twins	57	53	.518	110	3,738	515	950	207	16	130	492	322	71	860	40	16	4,170	1,579	353	7	32	8	80	.254	.323	.422	.745
16	Giants	56	54	.509	110	3,730	484	875	179	25	134	464	337	34	1,036	51	13	4,138	1,506	338	5	32	10	73	.235	.301	.404	.705
17	Red Sox	56	54	.509	110	3,806	532	977	215	17	141	513	337	47	1,068	107	30	4,221	1,649	373	2	29	21	76	.257	.323	.433	.756
18	Cubs	55	55	.500	110	3,734	514	929	181	18	120	488	356	45	926	111	18	4,169	1,506	319	12	22	12	59	.249	.320	.403	.723
19	Mariners	55	55	.500	110	3,626	471	809	165	6	126	445	411	93	1,104	111	18	4,169	1,364	297	13	26	11	74	.223	.316	.376	.692
20	Royals	53	55	.491	108	3,647	491	918	172	24	121	477	279	38	780	83	22	4,019	1,501	317	15	40	14	65	.252	.308	.412	.720
21	Rays	53	55	.491	108	3,583	392	812	177	17	104	371	331	51	1,001	124	31	3,992	1,335	298	5	22	11	52	.227	.299	.373	.672
22	Blue Jays	52	60	.464	112	3,788	485	930	197	23	114	465	342	59	877	45	13	4,231	1,515	334	8	34	17	80	.246	.315	.400	.715
23	Pirates	51	58	.468	109	3,697	464	889	164	14	106	451	295	49	1,004	78	13	4,082	1,399	284	8	33	7	66	.240	.303	.378	.681
24	Rangers	50	59	.459	109	3,649	434	853	147	6	116	415	313	37	869	75	21	4,024	1,360	269	5	20	12	61	.234	.299	.373	.672
25	Athletics	49	59	.454	108	3,644	449	871	164	12	135	431	326	31	982	76	16	4,037	1,464	311	10	26	6	76	.239	.305	.402	.707