Between the 1940 and 1949 seasons, Hal Newhouser struck out the most batters, with 1,579 strikeouts.

	NAME	SO	G	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Hal Newhouser H. Newhouser	1,579	377	170	118	.590	305	2.84	181	31	15	2453.1	2,127	774	927	84	1,068	10	56	10,360	52	5.79	3.92	1.48	0.31	15.2	10.3	1.30	.268	3.40	72	3.01	77	7.80	237.2
2	Bob Feller B. Feller	1,396	266	137	82	.626	231	2.90	155	28	16	1897.0	1,539	611	677	95	827	22	27	7,880	30	6.62	3.92	1.69	0.45	17.7	10.5	1.25	.261	3.21	76	3.11	83	7.30	133.9
3	Bobo Newsom B. Newsom	1,070	302	105	120	.467	261	3.59	115	19	5	1961.1	1,949	782	915	93	792	32	22	8,488	26	4.91	3.63	1.35	0.43	12.6	9.3	1.40	.285	4.20	97	3.33	90	8.94	87
4	Johnny Vander Meer J. Vander Meer	972	232	93	92	.503	219	3.32	103	26	1	1589.1	1,363	587	657	71	805	12	4	6,758	25	5.50	4.56	1.21	0.40	14.4	11.9	1.36	.264	3.72	92	3.41	94	7.72	36.5
5	Dizzy Trout D. Trout	930	374	129	119	.520	239	3.01	132	27	22	2026.1	1,944	678	821	74	746	21	93	8,587	36	4.13	3.31	1.25	0.33	10.8	8.7	1.33	.274	3.65	78	3.21	85	8.63	133.3
6	Kirby Higbe K. Higbe	853	354	105	83	.559	207	3.53	84	10	22	1692.2	1,492	663	759	102	819	25	82	7,273	47	4.54	4.35	1.04	0.54	11.7	11.3	1.37	.254	4.04	94	3.84	101	7.93	-6
7	Allie Reynolds A. Reynolds	791	247	103	68	.602	192	3.46	73	16	14	1484.0	1,340	571	635	77	799	29	39	6,422	36	4.80	4.85	0.99	0.47	12.3	12.4	1.44	.267	3.85	97	3.79	106	8.13	-39.4
8	Dutch Leonard D. Leonard	779	294	122	123	.498	273	3.14	139	23	2	2047.1	2,105	715	884	84	445	31	10	8,535	53	3.42	1.96	1.75	0.37	9.1	5.2	1.25	.281	3.89	85	3.04	83	9.25	148.4
9	Mort Cooper M. Cooper	772	246	114	68	.626	210	2.93	120	31	9	1606.1	1,441	523	598	77	462	25	26	6,627	24	4.33	2.59	1.67	0.43	11.6	7.0	1.18	.258	3.35	79	3.09	84	8.07	101
10	Virgil Trucks V. Trucks	760	215	87	63	.580	159	3.29	65	14	10	1281.2	1,126	469	530	81	491	14	37	5,391	28	5.34	3.45	1.55	0.57	14.1	9.1	1.26	.258	3.72	85	3.30	85	7.91	82
11	Tex Hughson T. Hughson	693	225	96	54	.640	156	2.94	99	19	17	1375.2	1,270	450	504	77	372	11	51	5,663	5	4.53	2.43	1.86	0.50	12.2	6.6	1.19	.265	3.30	79	3.01	82	8.31	98.8
12	Bucky Walters B. Walters	677	246	122	90	.575	238	2.97	153	28	3	1868.1	1,724	616	726	92	631	24	6	7,778	28	3.26	3.04	1.07	0.44	8.7	8.1	1.26	.257	3.50	84	3.53	99	8.30	5.6
13	Harry Brecheen H. Brecheen	666	216	105	59	.640	172	2.74	101	22	12	1388.0	1,242	422	480	68	378	27	30	5,662	14	4.32	2.45	1.76	0.44	11.8	6.7	1.17	.260	3.11	72	3.06	80	8.05	115.8
14	Joe Dobson J. Dobson	665	258	94	69	.577	182	3.57	80	17	8	1434.2	1,343	569	640	81	570	9	45	6,062	40	4.17	3.58	1.17	0.51	11.0	9.4	1.33	.266	4.01	89	3.55	90	8.42	67.4
15	Hank Borowy H. Borowy	650	261	104	76	.578	208	3.35	93	16	7	1607.1	1,542	599	692	96	567	5	35	6,772	28	3.64	3.17	1.15	0.54	9.6	8.4	1.31	.265	3.87	93	3.53	98	8.63	7.6
16	Claude Passeau C. Passeau	646	258	111	85	.566	207	2.94	130	21	12	1693.2	1,704	554	665	65	426	17	38	7,149	17	3.43	2.26	1.52	0.35	9.0	6.0	1.26	.273	3.53	84	3.07	87	9.05	88.7
17	Nels Potter N. Potter	644	272	82	73	.529	143	3.42	76	6	15	1377.1	1,324	524	585	82	445	14	93	5,806	28	4.21	2.91	1.45	0.54	11.1	7.7	1.28	.269	3.82	90	3.40	90	8.65	58.2
18	Bill Voiselle B. Voiselle	620	226	74	80	.481	183	3.76	74	13	3	1322.0	1,306	552	637	108	559	14	19	5,751	23	4.22	3.81	1.11	0.74	10.8	9.7	1.41	.269	4.34	100	3.95	105	8.89	-28.4
19	Johnny Niggeling J. Niggeling	599	172	61	68	.473	156	3.12	79	11	0	1208.1	1,056	419	504	58	502	32	12	5,133	33	4.46	3.74	1.19	0.43	11.7	9.8	1.29	.253	3.75	84	3.50	96	7.87	21.4
20	Max Lanier M. Lanier	588	194	77	47	.621	128	2.68	63	16	11	1030.2	922	307	373	23	365	10	39	4,258	9	5.13	3.19	1.61	0.20	13.8	8.6	1.25	.275	3.26	73	2.77	75	8.05	102.2
21	Denny Galehouse D. Galehouse	560	231	75	79	.487	183	3.64	76	15	6	1380.1	1,452	559	636	68	457	12	24	5,932	16	3.65	2.98	1.23	0.44	9.4	7.7	1.38	.286	4.15	93	3.38	87	9.47	75
22	Rip Sewell R. Sewell	548	316	133	87	.605	231	3.35	132	19	12	1894.0	1,864	706	848	101	646	20	55	8,102	26	2.60	3.07	0.85	0.48	6.8	8.0	1.33	.260	4.03	90	3.71	99	8.86	12.9
23	Spud Chandler S. Chandler	543	165	85	34	.714	151	2.67	89	22	6	1211.2	1,039	359	425	49	387	16	9	4,939	18	4.03	2.87	1.40	0.36	11.0	7.8	1.18	.251	3.16	72	3.14	87	7.72	61
24	Johnny Sain J. Sain	539	194	79	65	.549	147	3.28	90	11	10	1185.2	1,151	432	506	68	387	20	34	5,025	13	4.09	2.94	1.39	0.52	10.7	7.7	1.30	.270	3.84	88	3.38	90	8.74	47.4
25	Bob Muncrief B. Muncrief	522	283	80	82	.494	164	3.77	67	11	9	1393.1	1,488	583	659	104	383	15	71	5,921	20	3.37	2.47	1.36	0.67	8.8	6.5	1.34	.283	4.26	99	3.59	95	9.61	27.5