Don Sutton has the most career quality starts, with 483.

Interpreted as:

MLB regular-season quality start leaders

	NAME	QS	G	W	L	W%	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Don Sutton D. Sutton	483	774	324	256	.559	756	3.26	3,574	178	58	5	5282.1	4,692	1,914	2,104	472	1,343	82	12	103	21,631	112	6.09	2.29	2.66	0.80	16.5	6.2	1.14	.261	3.58	7.99
2	Nolan Ryan N. Ryan	481	807	324	292	.526	773	3.19	5,714	222	61	3	5386.0	3,923	1,911	2,178	321	2,795	158	13	78	22,575	277	9.55	4.67	2.04	0.54	25.3	12.4	1.25	.265	3.64	6.56
3	Greg Maddux G. Maddux	480	744	355	227	.610	740	3.16	3,371	109	35	0	5008.1	4,726	1,756	1,981	353	999	137	3	177	20,421	70	6.06	1.80	3.37	0.63	16.5	4.9	1.14	.281	3.56	8.49
4	Roger Clemens R. Clemens	465	709	354	184	.658	707	3.12	4,672	118	46	0	4916.2	4,185	1,707	1,885	363	1,580	159	0	63	20,240	143	8.55	2.89	2.96	0.66	23.1	7.8	1.17	.284	3.45	7.66
5	Tom Seaver T. Seaver	454	656	311	205	.603	647	2.86	3,640	231	61	1	4783.0	3,971	1,521	1,674	380	1,390	76	6	117	19,369	125	6.85	2.62	2.62	0.72	18.8	7.2	1.12	.259	3.15	7.47
6	Gaylord Perry G. Perry	453	777	314	265	.542	690	3.11	3,534	303	53	10	5350.0	4,938	1,846	2,128	399	1,378	108	33	163	21,953	160	5.95	2.32	2.56	0.67	16.1	6.3	1.18	.275	3.58	8.31
7	Steve Carlton S. Carlton	447	741	329	244	.574	709	3.22	4,136	254	55	2	5217.2	4,672	1,864	2,130	414	1,833	53	13	150	21,682	183	7.13	3.16	2.26	0.71	19.1	8.5	1.25	.279	3.67	8.06
8	Phil Niekro P. Niekro	442	864	318	274	.537	716	3.35	3,342	245	45	29	5404.0	5,044	2,012	2,337	482	1,809	123	83	86	22,677	227	5.57	3.01	1.85	0.80	14.7	8.0	1.27	.270	3.89	8.40
9	Tom Glavine T. Glavine	436	682	305	203	.600	682	3.54	2,607	56	25	0	4413.1	4,298	1,734	1,900	356	1,500	66	0	145	18,604	65	5.32	3.06	1.74	0.73	14.0	8.1	1.31	.280	3.87	8.76
10	Tommy John T. John	431	760	288	231	.555	700	3.34	2,245	162	46	3	4710.0	4,783	1,749	2,017	302	1,259	98	22	102	19,691	188	4.29	2.41	1.78	0.58	11.4	6.4	1.28	.284	3.85	9.14
11	Bert Blyleven B. Blyleven	429	692	287	250	.534	685	3.31	3,701	242	60	0	4970.0	4,632	1,830	2,029	430	1,322	155	3	71	20,492	114	6.70	2.39	2.80	0.78	18.1	6.5	1.20	.282	3.67	8.39
12	Warren Spahn W. Spahn	427	750	363	245	.597	665	3.09	2,583	382	63	28	5243.2	4,833	1,801	2,018	434	1,432	41	67		21,555	78	4.43	2.46	1.80	0.74	12.0	6.6	1.19	.258	3.46	8.30
13	Grover Alexander G. Alexander	407	696	373	208	.642	600	2.41	2,209	437	90	33	5182.2	4,866		1,851	165	951	67	80			38	3.84	1.65	2.32	0.29		4.5	1.12	.268	3.21	8.45
14	Randy Johnson R. Johnson	403	618	303	166	.646	603	3.29	4,875	100	37	2	4135.1	3,346	1,513	1,703	411	1,497	190	7	37	17,067	109	10.61	3.26	3.26	0.89	28.6	8.8	1.17	.291	3.71	7.28
15	Robin Roberts R. Roberts	369	676	286	245	.539	609	3.40	2,362	305	45	25	4688.2	4,582	1,773	1,962	505	901	54	49		19,222	34	4.53	1.73	2.62	0.97	12.3	4.7	1.17	.265	3.77	8.80
16	Frank Tanana F. Tanana	365	638	240	236	.504	616	3.66	2,773	143	34	1	4188.1	4,063	1,702	1,910	448	1,255	129	10	116	17,641	119	5.96	2.70	2.21	0.96	15.7	7.1	1.27	.277	4.10	8.73
17	Jim Kaat J. Kaat	365	898	283	237	.544	625	3.45	2,462	180	31	17	4530.0	4,620	1,738	2,038	395	1,083	122	102	117	19,026	128	4.89	2.15	2.27	0.78	12.9	5.7	1.26	.282	4.05	9.18
18	Fergie Jenkins F. Jenkins	358	664	284	226	.557	594	3.34	3,191	267	49	7	4500.2	4,142	1,669	1,853	484	997	84	37	117	18,404	62	6.38	1.99	3.20	0.97	17.3	5.4	1.14	.268	3.71	8.28
19	Early Wynn E. Wynn	358	691	300	244	.551	611	3.54	2,340	289	49	15	4564.0	4,292	1,793	2,037	339	1,775	64	67		19,406	53	4.61	3.50	1.32	0.67	12.1	9.1	1.33	.266	4.02	8.46
20	Walter Johnson W. Johnson	357	788	412	270	.604	654	1.73	3,456	520	108	34	5806.1	4,816		1,867	96	1,354	206	126			151	5.36	2.10	2.55	0.15		5.8	1.06	.261	2.89	7.46
21	Justin Verlander J. Verlander	347	526	262	147	.641	526	3.30	3,416	26	9	0	3415.2	2,891	1,252	1,354	355	952	115	0	27	13,945	97	9.00	2.51	3.59	0.94	24.5	6.8	1.13	.278	3.57	7.62
22	Eppa Rixey E. Rixey	343	692	266	251	.515	554	3.15	1,351	289	37	14	4493.0	4,639		1,993	93	1,084	77	100			97	2.71	2.17	1.25	0.19		5.8	1.27	.281	3.99	9.29
23	Jamie Moyer J. Moyer	341	696	269	209	.563	638	4.25	2,441	33	10	0	4074.0	4,231	1,926	2,076	522	1,155	146	15	69	17,356	57	5.39	2.55	2.11	1.15	14.1	6.7	1.32	.283	4.59	9.35
24	Rick Reuschel R. Reuschel	337	557	214	191	.528	529	3.37	2,015	102	26	5	3548.1	3,588	1,330	1,494	221	935	88	16	117	14,888	89	5.11	2.37	2.16	0.56	13.5	6.3	1.27	.290	3.79	9.10
25	Jim Palmer J. Palmer	337	558	268	152	.638	521	2.86	2,212	211	53	4	3948.0	3,349	1,253	1,395	303	1,311	38	15	37	16,117	87	5.04	2.99	1.69	0.69	13.7	8.1	1.18	.249	3.18	7.63